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6/29/2015 4:40:00 PM | Browse: 494 | Download: 531
Publication Name World Journal of Gastroenterology
Manuscript ID 15154
Country/Territory Israel
2014-11-11 08:47
Peer-Review Started
2014-11-12 15:38
To Make the First Decision
2015-01-08 16:59
Return for Revision
2015-01-12 17:52
2015-02-05 00:57
Second Decision
2015-03-25 16:33
Accepted by Journal Editor-in-Chief
2015-03-26 00:38
Accepted by Company Editor-in-Chief
2015-03-31 10:34
Articles in Press
2015-03-31 11:08
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-06-15 18:14
Publish the Manuscript Online
2015-06-29 16:33
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title Altered distribution of regulatory lymphocytes by oral administration of soy-extracts exerts a hepatoprotective effect alleviating immune mediated liver injury, non-alcoholic steatohepatitis and insulin resistance
Manuscript Source Unsolicited Manuscript
All Author List Tawfik Khoury, Ami Ben Ya'acov, Yehudit Shabat, Lidya Zolotarovya, Ram Snir and Yaron Ilan
Funding Agency and Grant Number
Funding Agency Grant Number
Roaman-Epstein Liver Research Foundation (partly, to Ilan Y)
Corresponding author Tawfik Khoury, MD, Gastroeneterology and Liver Units, Department of Medicine, Hadassah-Hebrew University Medical Center, PO Box 12000, Jerusalem IL-91120, Israel. tawfikkhoury1@hotmail.com
Keywords Non-alcoholic steatohepatitis; Fatty liver; Regulatory T cells; Soy; Type 2 diabetes; ConA hepatitis
Core Tip Oral administration of the combination of OS and M1 soy derived extracts exerted an adjuvant effect in the gut-immune system, altering the distribution of regulatory T cells, and alleviating immune mediated liver injury, hyperlipidemia and insulin resistance. Oral administration of these extracts had an additive effect in alleviating concanavalin A hepatitis and ameliorated liver injury in the high fat diet model of non-alcoholic steatohepatitis, and in the methionine and choline reduced diet combined with the high fat diet model. The effects were associated with reduced serum tumor necrosis factor alpha and alteration of regulatory T cell distribution.
Publish Date 2015-06-29 16:33
Citation Khoury T, Ben Ya'acov A, Shabat Y, Zolotarovya L, Snir R, Ilan Y. Altered distribution of regulatory lymphocytes by oral administration of soy-extracts exerts a hepatoprotective effect alleviating immune mediated liver injury, non-alcoholic steatohepatitis and insulin resistance. World J Gastroenterol 2015; 21(24): 7443-7456
Url http://www.wjgnet.com/1007-9327/full/v21/i24/7443.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i24.7443
Full Article (PDF) WJG-21-7443.pdf
Full Article (Word) WJG-21-7443.doc
Manuscript File 15154-Review.doc
Answering Reviewers 15154-Answering reviewers.pdf
Copyright License Agreement 15154-Copyright assignment.pdf
Institutional Review Board Approval Form or Document 15154-Institutional review board statement.pdf
Peer-review Report 15154-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 15154-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 15154-Scientific misconduct check.pdf
Scientific Editor Work List 15154-Scientific editor work list.pdf