Publication Name	World Journal of Gastroenterology
Manuscript ID	15154
Country	Israel

Received	2014-11-11 08:47
Peer-Review Started	2014-11-12 15:38
First Decision by Editorial Office Director
Return for Revision	2015-01-12 17:52
Revised	2015-02-05 00:57
Publication Fee Transferred
Second Decision by Editor	2015-03-25 16:33
Second Decision by Editor-in-Chief	2015-03-26 00:38
Final Decision by Editorial Office Director	2015-03-31 10:34
Articles in Press	2015-03-31 11:08
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-06-15 18:14
Publish the Manuscript Online	2015-06-29 16:33

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Altered distribution of regulatory lymphocytes by oral administration of soy-extracts exerts a hepatoprotective effect alleviating immune mediated liver injury, non-alcoholic steatohepatitis and insulin resistance
Manuscript Source	Unsolicited Manuscript
All Author List	Tawfik Khoury, Ami Ben Ya'acov, Yehudit Shabat, Lidya Zolotarovya, Ram Snir and Yaron Ilan
Funding Agency and Grant Number	Funding Agency Grant Number Roaman-Epstein Liver Research Foundation (partly, to Ilan Y)
Corresponding Author	Tawfik Khoury, MD, Gastroeneterology and Liver Units, Department of Medicine, Hadassah-Hebrew University Medical Center, PO Box 12000, Jerusalem IL-91120, Israel. tawfikkhoury1@hotmail.com
Key Words	Non-alcoholic steatohepatitis; Fatty liver; Regulatory T cells; Soy; Type 2 diabetes; ConA hepatitis
Core Tip	Oral administration of the combination of OS and M1 soy derived extracts exerted an adjuvant effect in the gut-immune system, altering the distribution of regulatory T cells, and alleviating immune mediated liver injury, hyperlipidemia and insulin resistance. Oral administration of these extracts had an additive effect in alleviating concanavalin A hepatitis and ameliorated liver injury in the high fat diet model of non-alcoholic steatohepatitis, and in the methionine and choline reduced diet combined with the high fat diet model. The effects were associated with reduced serum tumor necrosis factor alpha and alteration of regulatory T cell distribution.
Publish Date	2015-06-29 16:33
Citation	Khoury T, Ben Ya'acov A, Shabat Y, Zolotarovya L, Snir R, Ilan Y. Altered distribution of regulatory lymphocytes by oral administration of soy-extracts exerts a hepatoprotective effect alleviating immune mediated liver injury, non-alcoholic steatohepatitis and insulin resistance. World J Gastroenterol 2015; 21(24): 7443-7456
URL	http://www.wjgnet.com/1007-9327/full/v21/i24/7443.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i24.7443

Full Article (PDF)	WJG-21-7443.pdf
Full Article (Word)	WJG-21-7443.doc