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Articles Published Processes
6/29/2015 4:40:00 PM | Browse: 1046 | Download: 1196
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Received |
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2014-11-11 08:47 |
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Peer-Review Started |
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2014-11-12 15:38 |
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To Make the First Decision |
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2015-01-08 16:59 |
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Return for Revision |
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2015-01-12 17:52 |
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Revised |
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2015-02-05 00:57 |
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Second Decision |
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2015-03-25 16:33 |
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Accepted by Journal Editor-in-Chief |
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2015-03-26 00:38 |
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Accepted by Company Editor-in-Chief |
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2015-03-31 10:34 |
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Articles in Press |
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2015-03-31 11:08 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-06-15 18:14 |
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Publish the Manuscript Online |
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2015-06-29 16:33 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Altered distribution of regulatory lymphocytes by oral administration of soy-extracts exerts a hepatoprotective effect alleviating immune mediated liver injury, non-alcoholic steatohepatitis and insulin resistance
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Tawfik Khoury, Ami Ben Ya'acov, Yehudit Shabat, Lidya Zolotarovya, Ram Snir and Yaron Ilan |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Roaman-Epstein Liver Research Foundation (partly, to Ilan Y) |
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| Corresponding Author |
Tawfik Khoury, MD, Gastroeneterology and Liver Units, Department of Medicine, Hadassah-Hebrew University Medical Center, PO Box 12000, Jerusalem IL-91120, Israel. tawfikkhoury1@hotmail.com |
| Key Words |
Non-alcoholic steatohepatitis; Fatty liver; Regulatory T cells; Soy; Type 2 diabetes; ConA hepatitis |
| Core Tip |
Oral administration of the combination of OS and M1 soy derived extracts exerted an adjuvant effect in the gut-immune system, altering the distribution of regulatory T cells, and alleviating immune mediated liver injury, hyperlipidemia and insulin resistance. Oral administration of these extracts had an additive effect in alleviating concanavalin A hepatitis and ameliorated liver injury in the high fat diet model of non-alcoholic steatohepatitis, and in the methionine and choline reduced diet combined with the high fat diet model. The effects were associated with reduced serum tumor necrosis factor alpha and alteration of regulatory T cell distribution. |
| Publish Date |
2015-06-29 16:33 |
| Citation |
Khoury T, Ben Ya'acov A, Shabat Y, Zolotarovya L, Snir R, Ilan Y. Altered distribution of regulatory lymphocytes by oral administration of soy-extracts exerts a hepatoprotective effect alleviating immune mediated liver injury, non-alcoholic steatohepatitis and insulin resistance. World J Gastroenterol 2015; 21(24): 7443-7456 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i24/7443.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i24.7443 |
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