| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
|
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Randomized Controlled Trial |
| Article Title |
Recombinant streptokinase vs hydrocortisone suppositories in acute hemorrhoids: A randomized controlled trial
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Francisco Hernández-Bernal, Georgina Castellanos-Sierra, Carmen M Valenzuela-Silva, Karem M Catasús-Álvarez, Osmany Martínez-Serrano, Odalys C Lazo-Diago, Cimara H Bermúdez-Badell, José R Causa-García, Juan E Domínguez-Suárez and Pedro A López-Saura; THERESA-4 (Treatment of HEmorrhoids with REcombinant Streptokinase Application) Group of Investigators |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Heber Biotec, Havana |
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| Corresponding Author |
Francisco Hernández-Bernal, MD, MSc, Clinical Research Direction, Center for Genetic Engineering and Biotechnology, P.O. Box 6162, Havana 74110, Cuba. hernandez.bernal@cigb.edu.cu
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| Key Words |
Streptokinase; Suppository; Hydrocortisone acetate; Thrombolysis; Hemorrhoids; Randomized clinical trial |
| Core Tip |
Medical treatments for acute hemorrhoidal disease come very seldom from randomized, controlled clinical trials. The paper describes that recombinant streptokinase suppositories, a candidate to a new therapeutic alternative, based on thrombolysis, shows significant efficacy advantage with respect to hydrocortisone acetate, a widely used, over-the-counter product. |
| Publish Date |
2015-06-20 17:38 |
| Citation |
Hernández-Bernal F, Castellanos-Sierra G, Valenzuela-Silva CM, Catasús-Álvarez KM, Martínez-Serrano O, Lazo-Diago OC, Bermúdez-Badell CH, Causa-García JR, Domínguez-Suárez JE, López-Saura PA; THERESA-4 (Treatment of HEmorrhoids with REcombinant Streptokinase Application) Group of Investigators. Recombinant streptokinase vs hydrocortisone suppositories in acute hemorrhoids: A randomized controlled trial. World J Gastroenterol 2015; 21(23): 7305-7312 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i23/7305.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i23.7305 |
