Publication Name	World Journal of Nephrology
Manuscript ID	15198
Country	Denmark

Received	2014-11-14 09:32
Peer-Review Started	2014-11-18 08:48
To Make the First Decision	2015-02-07 15:02
Return for Revision	2015-02-10 15:37
Revised	2015-03-08 17:19
Second Decision	2015-04-20 11:38
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-04-30 11:27
Articles in Press	2015-04-30 11:27
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-07-01 10:37
Publish the Manuscript Online	2015-07-06 18:45

ISSN	2220-6124 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Physiology
Manuscript Type	Randomized Controlled Trial
Article Title	Changes in urinary excretion of water and sodium transporters during amiloride and bendroflumethiazide treatment
Manuscript Source	Unsolicited Manuscript
All Author List	Janni M Jensen, Frank Hn Mose, Anna-Ewa O Kulik, Jesper N Bech, Robert A Fenton and Erling B Pedersen
Funding Agency and Grant Number	Funding Agency Grant Number Lundbeck Foundation Aase and Ejnar Danielsens Foundation Helen and Ejnar Bjoernows Foundation Region Midjutlands Research Fund
Corresponding Author	Janni M Jensen, PhD, University Clinic in Nephrology and Hypertension, Department of Medical Research, Holstebro Hospital, Laegaardvej 12, 7500 Holstebro, Denmark. jannimaj@gmail.com
Key Words	Amiloride; Thiazide; Sodium-potassium-chloride co-transporter; Aquaporin2; Epithelial sodium channels; Sodium; Water; Sodium transporters; Hypertonic saline; Urine
Core Tip	Measurements of urinary sodium-potassium chloride co-transporter (NKCC2), epithelial sodium channel (ENaC) and aquaporin2 (AQP2) can be used as biomarkers of water- and sodium transport in the nephron. However, it has never been studied to what extent the function of NKCC2, ENaC and AQP2 is simultaneously affected in response to diuretics. The present study showed that infusion of 3% saline increased u-NKCC2 and u-AQP2 during amiloride and placebo, while u-NKCC2 and u-AQP2 remained unchanged during bendroflumethiazide. Therefor, in contrast to amiloride, bendroflumethiazide caused the absence of a compensatory reabsorption of sodium via NKCC2 and water via AQP2.
Publish Date	2015-07-06 18:45
Citation	Jensen JM, Mose FH, Kulik AEO, Bech JN, Fenton RA, Pedersen EB. Changes in urinary excretion of water and sodium transporters during amiloride and bendroflumethiazide treatment. World J Nephrol 2015; 4(3): 423-437
URL	http://www.wjgnet.com/2220-6124/full/v4/i3/423.htm
DOI	http://dx.doi.org/10.5527/wjn.v4.i3.423

Full Article (PDF)	WJN-4-423.pdf
Full Article (Word)	WJN-4-423.doc
Manuscript File	15198-Review.docx
Answering Reviewers	15198-Answering reviewers.pdf
Audio Core Tip	15198-Audio core tip.mp3
Biostatistics Review Certificate	15198-Biostatistics statement.pdf
Clinical Trial Registration Statement	15198-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form	15198-Conflict-of-interest statement.pdf
Copyright License Agreement	15198-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	15198-Clinical trial registration statement.pdf
Institutional Review Board Approval Form or Document	15198-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	15198-Language certificate.pdf
Peer-review Report	15198-Peer-review(s).pdf
Scientific Misconduct Check	15198-Scientific misconduct check.pdf
Scientific Editor Work List	15198-Scientific editor work list.pdf