Publication Name	World Journal of Gastroenterology
Manuscript ID	15210
Country	China

Received	2014-11-15 17:50
Peer-Review Started	2014-11-17 13:58
To Make the First Decision	2014-12-11 20:28
Return for Revision	2014-12-16 18:50
Revised	2014-12-31 12:07
Second Decision	2015-02-06 09:06
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-02-12 17:49
Articles in Press	2015-02-13 11:23
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-03-23 20:53
Typeset the Manuscript	2015-04-08 15:55
Publish the Manuscript Online	2015-04-20 15:10

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Contrast-enhanced ultrasound for quantitative assessment of portal pressure in canine liver fibrosis
Manuscript Source	Unsolicited Manuscript
All Author List	Lin Zhai, Lan-Yan Qiu, Yuan Zu, Yan Yan, Xiao-Zhuan Ren, Jun-Feng Zhao, Yu-Jiang Liu, Ji-Bin Liu and Lin-Xue Qian
Funding Agency and Grant Number
Corresponding Author	Lin-Xue Qian, MD, Department of Ultrasonography, Beijing Friendship Hospital, Capital Medical University, No. 95 Yongan Road, Beijing 100050, China. Qianlinxue2002@163.com
Key Words	Animal model; Contrast-enhanced ultrasound; Liver fibrosis; Noninvasive technique; Portal venous pressure
Core Tip	The measurement of portal pressure plays an important role in the evaluation of the progression of liver disease. Contrast-enhanced ultrasound techniques can provide hemodynamic parameters of blood circulation and tissue perfusion. The introduction of the area under the time-intensity curve and intensity at portal/arterial phases parameters has obvious advantages over absolute values, such as peak intensity, as the approach reduces other sources of interference. These parameters were negatively correlated with free portal pressure, supporting the use of contrast-enhanced ultrasound as a method to noninvasively estimate portal pressure.
Publish Date	2015-04-20 15:10
Citation	Zhai L, Qiu LY, Zu Y, Yan Y, Ren XZ, Zhao JF, Liu YJ, Liu JB, Qian LX. Contrast-enhanced ultrasound for quantitative assessment of portal pressure in canine liver fibrosis. World J Gastroenterol 2015; 21(15): 4509-4516
URL	http://www.wjgnet.com/1007-9327/full/v21/i15/4509.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i15.4509

Full Article (PDF)	WJG-21-4509.pdf
Full Article (Word)	WJG-21-4509.doc
Manuscript File	15210-Review.docx
Answering Reviewers	15210-Answering reviewers.pdf
Copyright License Agreement	15210-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document	15210-Institutional animal care and use committee statement.pdf
Peer-review Report	15210-Peer-review(s).pdf
Scientific Misconduct Check	15210-Scientific misconduct check.pdf
Scientific Editor Work List	15210-Scientific editor work list.pdf