Publication Name	World Journal of Transplantation
Manuscript ID	15252
Country	Mexico

Received	2014-11-18 08:42
Peer-Review Started	2014-11-18 15:24
To Make the First Decision	2014-12-26 13:30
Return for Revision	2015-01-05 16:16
Revised	2015-01-13 13:53
Second Decision	2015-02-10 21:21
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-02-11 15:34
Articles in Press	2015-02-11 16:18
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-03-11 16:49
Typeset the Manuscript	2015-04-26 16:30
Publish the Manuscript Online	2015-05-18 17:02

ISSN	2220-3230 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Neurosciences
Manuscript Type	Review
Article Title	Historical perspective of cell transplantation in Parkinson’s disease
Manuscript Source	Invited Manuscript
All Author List	Jin-Zhou Zhu, Qin-Yi Zhou, Yu-Ming Wang, Yi-Ning Dai, Jiang Zhu, Chao-Hui Yu and You-Ming Li
Funding Agency and Grant Number
Corresponding Author	René Drucker-Colín, PhD, Departamento de Neuropatología Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Circuito Exterior s/n, Ciudad Universitaria, 04910 Ciudad de México, México. drucker@unam.mx
Key Words	Parkinson’s disease; Cell replacement; Animal models; Nigrostriatal pathway; Dopaminergic loss
Core Tip	The first studies on cell transplantation for Parkinson’s disease (PD) were published during the early 80s. Since then, it has been shown that different cell types induce functional benefits but with high variability among subjects. Here, we first provide a general overview of the field during its early years. Then, we discuss some factors associated with the functionality of the graft based on the latest findings, and highlight the importance of understanding basic aspects (e.g., factors influencing graft integration) which ultimately could contribute to reducing the variability of the functional outcome –an important requirement for its application in the clinic.
Publish Date	2015-05-18 17:02
Citation	Boronat-García A, Guerra-Crespo M, Drucker-Colín R. Historical Perspective of cell transplantation in Parkinson’s disease. World J Transplant 2017; In press
URL	http://www.wjgnet.com/1007-9327/full/v21/i18/5695.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i18.5695

Full Article (PDF)	WJG-21-5695.pdf
Full Article (Word)	WJG-21-5695.doc
Manuscript File	15252-Review.docx
Answering Reviewers	15252-Answering reviewers.pdf
Biostatistics Review Certificate	15252-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	15252-Conflict-of-interest statement.pdf
Copyright License Agreement	15252-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	15252-Language certificate.pdf
Peer-review Report	15252-Peer-review(s).pdf
Scientific Misconduct Check	15252-Scientific misconduct check.pdf
Scientific Editor Work List	15252-Scientific editor work list.pdf