Publication Name	World Journal of Gastrointestinal Pharmacology and Therapeutics
Manuscript ID	15258
Country	Germany

Received	2014-11-18 08:23
Peer-Review Started	2014-11-18 20:19
To Make the First Decision	2014-12-12 17:24
Return for Revision	2014-12-29 15:38
Revised	2015-01-10 05:06
Second Decision	2015-05-07 09:44
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-05-18 16:57
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-07-28 20:31
Publish the Manuscript Online	2015-08-08 13:26

ISSN	2150-5349 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Nociceptin effect on intestinal motility depends on opioid-receptor like-1 receptors and nitric oxide synthase co-localization
Manuscript Source	Unsolicited Manuscript
All Author List	Andrei Sibaev, Jakub Fichna, Dieter Saur, Birol Yuece, Jean-Pierre Timmermans and Martin Storr
Funding Agency and Grant Number	Funding Agency Grant Number Deutsche Forschungsgemeinschaft STO 645/2-1(to Storr M) Deutsche Forschungsgemeinschaft YU132/2-1(to Yuece B) Society of Gastroenterology in Bavaria to Storr M Förderprogramm für Forschung to Yuece B, University of Calgary Research Grant Committee to Storr M Iuventus Plus program of the Polish Ministry of Science and Higher Education #0107/IP1/2013/72(to Fichna J) Medical University of Lodz #503/1-156-04/503-01(to Fichna J) National Science Centre #UMO-2013/11/B/NZ7/01301(to Fichna J)
Corresponding Author	Martin Storr, MD, PhD, Department of Medicine, Division of Gastroenterology, Ludwig Maximilians University of Munich, Marchioninistrasse 15, 81377 Munich, Germany. martin.storr@med.uni-muenchen.de
Key Words	Nociceptin; Gastrointestinal transit; Opioid-receptor like-1; Electrophysiology; Expression
Core Tip	Here we aimed to study the effect of the endogenous opioid-receptor like-1 (ORL1) agonist nociceptin on gastrointestinal (GI) myenteric neuro-transmission and motility. We observed that nociceptin reduces excitatory and inhibitory neurotransmission in motorneurons and interneurons and the overall effect on the GI tract may depend on co-localization of ORL1 receptors with nitric oxide synthase. Since ORL1 activation, unlike other opioid receptor-active drugs, is not associated with central side effects, compounds acting at the ORL1 may be good candidates for the future treatment of disorders associated with increased colonic transit, such as diarrhea or diarrhea-predominant irritable bowel syndrome.
Publish Date	2015-08-08 13:26
Citation	Sibaev A, Fichna J, Saur D, Yuece B, Timmermans JP, Storr M. Nociceptin effect on intestinal motility depends on opioid-receptor like-1 receptors and nitric oxide synthase co-localization. World J Gastrointest Pharmacol Ther 2015; 6(3): 73-83
URL	http://www.wjgnet.com/2150-5349/full/v6/i3/73.htm
DOI	http://dx.doi.org/10.4292/wjgpt.v6.i3.73

Full Article (PDF)	WJGPT-6-73.pdf
Full Article (Word)	WJGPT-6-73.doc
Manuscript File	15258-Review.docx
Answering Reviewers	15258-Answering reviewers.pdf
Audio Core Tip	15258-Audio core tip.mp3
Biostatistics Review Certificate	15258-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	15258-Conflict-of-interest statement.pdf
Copyright License Agreement	15258-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document	15258-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	15258-Institutional review board statement.pdf
Peer-review Report	15258-Peer-review(s).pdf
Scientific Misconduct Check	15258-Scientific misconduct check.pdf
Scientific Editor Work List	15258-Scientific editor work list.pdf