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Articles Published Processes
5/20/2015 5:01:00 PM | Browse: 1070 | Download: 1930
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Received |
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2014-11-18 16:54 |
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Peer-Review Started |
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2014-11-19 08:54 |
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To Make the First Decision |
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2014-12-26 13:30 |
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Return for Revision |
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2015-01-05 09:45 |
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Revised |
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2015-01-15 11:36 |
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Second Decision |
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2015-02-10 21:22 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2015-02-11 15:39 |
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Articles in Press |
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2015-02-11 16:18 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2015-03-19 20:26 |
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Typeset the Manuscript |
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2015-05-11 11:10 |
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Publish the Manuscript Online |
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2015-05-20 17:01 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Hepatocyte nuclear factor 4α induces a tendency of differentiation and activation of rat hepatic stellate cells
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Kai Liu, Ming-Gao Guo, Xiao-Li Lou, Xiao-Ya Li, Yang Xu, Wei-Dan Ji, Xuan-Dong Huang, Jia-He Yang and Ji-Cheng Duan |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81070359 |
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| Corresponding Author |
Ji-Cheng Duan, MD, Department of Molecular Oncology and Laparoscopic Surgery, Eastern Hepatobiliary Surgery Hospital and National Center of Liver Cancer, Second Military Medical University, Xiang Yin Road No. 800, Shanghai 200438, China. jichengduanren@163.com |
| Key Words |
Hepatocyte nuclear factor 4α; Hepatic stellate cells; Adenovirus vector; Differentiation; Rat |
| Core Tip |
Hepatocyte nuclear factor 4α (HNF4α) is an important transcription factor in liver differentiation. When enhanced HNF4α expression in hepatic stellate cell line hepatic stellate cells (HSCs)-T6, the expression of G-P-6, PEPCK and E-cadherin was up-regulated, the expression of Type I collagen, α-SMA, TIMP-1 and vimentin was down-regulated, and the induced cells were positive for AFP and ALB. When silencing HNF4α expression with shRNA vector, EPCK and E-cadherin were down-regulated and α-SMA and vimentin were up-regulated. The results demonstrated that HNF4α can induce a tendency of differentiation of HSCs into hepatocyte-like cells. The findings may provide an effective way for treatment of liver diseases. |
| Publish Date |
2015-05-20 17:01 |
| Citation |
Liu K, Guo MG, Lou XL, Li XY, Xu Y, Ji WD, Huang XD, Yang JH, Duan JC. Hepatocyte nuclear factor 4α induces a tendency of differentiation and activation of rat hepatic stellate cells. World J Gastroenterol 2015; 21(19): 5856-5866 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i19/5856.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i19.5856 |
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