Publication Name	World Journal of Gastroenterology
Manuscript ID	15278
Country	Spain

Received	2014-11-19 08:30
Peer-Review Started	2014-11-19 09:11
First Decision by Editorial Office Director
Return for Revision	2014-12-04 18:10
Revised	2014-12-10 02:10
Publication Fee Transferred
Second Decision by Editor	2015-01-23 15:48
Second Decision by Editor-in-Chief	2015-01-25 23:14
Final Decision by Editorial Office Director	2015-02-05 16:50
Articles in Press	2015-02-05 17:38
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-03-18 11:24
Publish the Manuscript Online	2015-03-30 14:23

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Hepatitis C virus-specific cytotoxic T cell response restoration after treatment-induced hepatitis C virus control
Manuscript Source	Invited Manuscript
All Author List	Juan-Ramón Larrubia, Elia Moreno-Cubero, Joaquín Miquel and Eduardo Sanz-de-Villalobos
Funding Agency and Grant Number	Funding Agency Grant Number “Instituto de Salud Carlos III”, Spain “European Regional Development Fund, a way of making Europe”, E.U. PI12/00130 “Asociación de Hepatología Translacional” Research Award 2014 to Moreno-Cubero E
Corresponding Author	Juan-Ramón Larrubia, MD, MSc, PhD, Translational Hepatology Unit, Guadalajara University Hospital, University of Alcalá, E-19002 Guadalajara, Spain. juan.larrubia@uah.es
Key Words	Hepatitis C virus; Chronic hepatitis; Hepatitis C virus-specific cytotoxic T cell response; Treatment; Direct-acting antivirals; Interferon-alpha; Ribavirin; Exhaustion; Apoptosis
Core Tip	Hepatitis C virus (HCV)-specific cytotoxic T lymphocyte (CTL) response plays an essential role in controlling acute HCV infection but its implication in treatment-induced viral control is controversial. During interferon/ribavirin treatment, HCV traces persist after sustained viral response (SVR) and this correlates with an activated HCV-specific CTL response, suggesting the necessity of this response to obtain an indefinite viral control. Current data propose that viral suppression during interferon/ribavirin treatment and during direct-acting anti-viral regimes could affect HCV-specific CTL restoration. Moreover, the features of this CTL response during treatment could have a predictive value on SVR outcome.
Publish Date	2015-03-30 14:23
Citation	Larrubia JR, Moreno-Cubero E, Miquel J, Sanz-de-Villalobos E. Hepatitis C virus-specific cytotoxic T cell response restoration after treatment-induced hepatitis C virus control. World J Gastroenterol 2015; 21(12): 3480-3491
URL	http://www.wjgnet.com/1007-9327/full/v21/i12/3480.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i12.3480

Full Article (PDF)	WJG-21-3480.pdf
Full Article (Word)	WJG-21-3480.doc
Manuscript File	15278-Review.docx
Answering Reviewers	15278-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	15278-Conflict-of-interest statement.pdf
Copyright License Agreement	15278-Copyright assignment.pdf
Peer-review Report	15278-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	15278-Journal Editor-in-Chief's Review Report.pdf
Scientific Misconduct Check	15278-Scientific misconduct check.pdf
Scientific Editor Work List	15278-Scientific editor work list.pdf