Publication Name	World Journal of Hepatology
Manuscript ID	15284
Country	Italy

Received	2014-11-19 08:53
Peer-Review Started	2014-11-22 10:30
First Decision by Editorial Office Director
Return for Revision	2014-12-31 10:10
Revised	2015-01-21 00:40
Publication Fee Transferred
Second Decision by Editor	2015-01-28 11:51
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2015-02-09 10:35
Articles in Press	2015-02-09 10:35
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-05-05 15:04
Publish the Manuscript Online	2015-05-20 16:43

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Valproic acid and nonalcoholic fatty liver disease: A possible association?
Manuscript Source	Invited Manuscript
All Author List	Edoardo Farinelli, David Giampaoli, Anja Cenciarini, Ephraim Cercado and Alberto Verrotti
Funding Agency and Grant Number
Corresponding Author	Alberto Verrotti, MD, PhD, Department of Pediatrics, University of Perugia, Via G. Dottori 1, 06100 Perugia, Italy. averrott@unich.it
Key Words	Nonalcoholic fatty liver disease; Valproic acid; Obesity; Insulin resistance
Core Tip	Nonalcoholic fatty liver disease (NAFLD) is a major medical issue worldwide. It affects 20%-25% of the general population including children. The term NAFLD covers a wide spectrum of hepatic diseases. These diseases include simple hepatic steatosis, inflammation, cirrhosis and the development of hepatocellular carcinoma. Valproic acid (VPA), one of the most used anti-epileptic drugs, has been investigated as a contributing factor for the development of NAFLD. This association seems stronger with long term VPA therapy. Further studies are required to determine the mechanism of this association.
Publish Date	2015-05-20 16:43
Citation	Farinelli E, Giampaoli D, Cenciarini A, Cercado E, Verrotti A. Valproic acid and nonalcoholic fatty liver disease: A possible association? World J Hepatol 2015; 7(9): 1251-1257
URL	http://www.wjgnet.com/1948-5182/full/v7/i9/1251.htm
DOI	http://dx.doi.org/10.4254/wjh.v7.i9.1251

Full Article (PDF)	WJH-7-1251.pdf
Full Article (Word)	WJH-7-1251.doc
Manuscript File	15284-Review.docx
Answering Reviewers	15284-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	15284-Conflict-of-interest statement.pdf
Copyright License Agreement	15284-Copyright assignment.pdf
Peer-review Report	15284-Peer-review(s).pdf
Scientific Misconduct Check	15284-Scientific misconduct check.pdf
Scientific Editor Work List	15284-Scientific editor work list.pdf