Publication Name	World Journal of Cardiology
Manuscript ID	15291
Country	Italy

Received	2014-11-20 09:17
Peer-Review Started	2014-11-20 14:41
To Make the First Decision	2014-12-12 17:23
Return for Revision	2014-12-18 15:57
Revised	2014-12-21 23:24
Second Decision	2015-05-08 17:46
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-05-18 17:15
Articles in Press	2015-05-18 17:15
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-08-14 19:14
Publish the Manuscript Online	2015-08-27 11:20

ISSN	1949-8462 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Cardiac & Cardiovascular Systems
Manuscript Type	Minireviews
Article Title	Clinical significance of lactate in acute cardiac patients
Manuscript Source	Invited Manuscript
All Author List	Chiara Lazzeri, Serafina Valente, Marco Chiostri and Gian Franco Gensini
Funding Agency and Grant Number
Corresponding Author	Chiara Lazzeri, MD, Intensive Cardiac Care Unit, Heart and Vessel Department, Azienda Ospedaliero-Universitaria Careggi, Viale Morgagni 85, 50134 Florence, Italy. lazzeric@libero.it
Key Words	Lactate; Acute coronary syndrome; Cardio­genic shock; Cardiac arrest; Therapeutic hypothermia; Extracorporeal membrane oxygenation; Prognosis
Core Tip	The present review is focused on the prog-nostic role of lactate levels in acute cardiac patients (acute coronary syndrome, cardiogenic shock, cardiac arrest). The prognostic impact of hyperlactatemia on mortality has been documented in cardiogenic shock and cardiac arrest even if there is no cut-off value of lactate to be associated with worse outcome or to guide resuscitation or hemodynamic management. Lactate clearance was reported to be clinically more reliable than lactate absolute value in these patients. Despite differences in study design, timing of lactate measurements and type of acute cardiac conditions (i.e., cardiogenic shock, cardiac arrest, refractory cardiac arrest), available evidence strongly suggests that higher lactate levels can be observed on admission in non-survivors and that a more favorable outcome is observed in patients with higher lactate clearance.
Publish Date	2015-08-27 11:20
Citation	Lazzeri C, Valente S, Chiostri M, Gensini GF. Clinical significance of lactate in acute cardiac patients. World J Cardiol 2015; 7(8): 483-489
URL	http://www.wjgnet.com/1949-8462/full/v7/i8/483.htm
DOI	http://dx.doi.org/10.4330/wjc.v7.i8.483

Full Article (PDF)	WJC-7-483.pdf
Full Article (Word)	WJC-7-483.doc
Manuscript File	15291-Review.doc
Answering Reviewers	15291-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	15291-Conflict-of-interest statement.pdf
Copyright License Agreement	15291-Copyright assignment.pdf
Peer-review Report	15291-Peer-review(s).pdf
Scientific Misconduct Check	15291-Scientific misconduct check.pdf
Scientific Editor Work List	15291-Scientific editor work list.pdf