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4/30/2015 2:11:00 PM | Browse: 835 | Download: 1363
Publication Name World Journal of Gastroenterology
Manuscript ID 15306
Country/Territory China
Received
2014-11-21 13:52
Peer-Review Started
2014-11-21 14:23
To Make the First Decision
2014-12-11 20:18
Return for Revision
2014-12-24 10:19
Revised
2014-12-29 11:03
Second Decision
2015-02-10 21:24
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2015-02-11 15:45
Articles in Press
2015-02-11 16:19
Publication Fee Transferred
Edit the Manuscript by Language Editor
2015-02-27 15:08
Typeset the Manuscript
2015-04-01 13:03
Publish the Manuscript Online
2015-04-20 15:10
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Biochemistry & Molecular Biology
Manuscript Type Observational Study
Article Title Human epidermal growth factor receptor 2 amplification and protein expression in mixed gastric carcinoma
Manuscript Source Unsolicited Manuscript
All Author List Yang-Kun Wang, Zhong Chen, Tian Yun, Cong-Yang Li, Bo Jiang, Xue-Xia Lv, Guang-Hui Chu, Su-Nan Wang, Hui Yan and Chun-Fang Gao
Funding Agency and Grant Number
Corresponding Author Yang-Kun Wang, Professor, Department of Pathology, 150th Luoyang Center Hospital, HuaXia West Road No. 2, Gaoxin District, Henan Province, China. wyk_150@163.com
Key Words Stomach; Gastric pathology; Human epidermal growth factor receptor 2; Fluorescence in situ hybridization; Immunohistochemistry
Core Tip Human epidermal growth factor receptor 2 (HER2) detection in mixed gastric carcinoma displays high heterogeneity; a standard detection of HER2 in mixed gastric cancer is needed to better guide therapeutic interventions. In this study, we utilized immunohistochemistry (IHC) to detect HER2 protein expression and fluorescence in situ hybridization (FISH) to detect HER2 amplification. We classified HER2 positive staining range by IHC as extensive, partial, and focal types, and defined HER2 amplification patterns by FISH as cluster, large granule, dot, and HH-17 categories. Clinical therapeutic findings of our patients validated our approaches for assessing the level of HER2 amplification and protein expression, and proved that these parameters are clinically useful.
Publish Date 2015-04-20 15:10
Citation Wang YK, Chen Z, Yun T, Li CY, Jiang B, Lv XX, Chu GH, Wang SN, Yan H, Shi LF. Human epidermal growth factor receptor 2 expression in mixed gastric carcinoma. World J Gastroenterol 2015; 21(15): 4680-4687
URL http://www.wjgnet.com/1007-9327/full/v21/i15/4680.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i15.4680
Full Article (PDF) WJG-21-4680.pdf
Full Article (Word) WJG-21-4680.doc
Manuscript File 15306-Review.doc
Answering Reviewers 15306-Answering reviewers.pdf
Biostatistics Review Certificate 15306-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 15306-Conflict-of-interest statement.pdf
Copyright License Agreement 15306-Copyright assignment.pdf
Institutional Review Board Approval Form or Document 15306-Institutional review board statement.pdf
Peer-review Report 15306-Peer-review(s).pdf
Scientific Misconduct Check 15306-Scientific misconduct check.pdf
Scientific Editor Work List 15306-Scientific editor work list.pdf