Publication Name	World Journal of Gastroenterology
Manuscript ID	15306
Country	China

Received	2014-11-21 13:52
Peer-Review Started	2014-11-21 14:23
To Make the First Decision	2014-12-11 20:18
Return for Revision	2014-12-24 10:19
Revised	2014-12-29 11:03
Second Decision	2015-02-10 21:24
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-02-11 15:45
Articles in Press	2015-02-11 16:19
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-02-27 15:08
Typeset the Manuscript	2015-04-01 13:03
Publish the Manuscript Online	2015-04-20 15:10

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Biochemistry & Molecular Biology
Manuscript Type	Observational Study
Article Title	Human epidermal growth factor receptor 2 amplification and protein expression in mixed gastric carcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Yang-Kun Wang, Zhong Chen, Tian Yun, Cong-Yang Li, Bo Jiang, Xue-Xia Lv, Guang-Hui Chu, Su-Nan Wang, Hui Yan and Chun-Fang Gao
Funding Agency and Grant Number
Corresponding Author	Yang-Kun Wang, Professor, Department of Pathology, 150th Luoyang Center Hospital, HuaXia West Road No. 2, Gaoxin District, Henan Province, China. wyk_150@163.com
Key Words	Stomach; Gastric pathology; Human epidermal growth factor receptor 2; Fluorescence in situ hybridization; Immunohistochemistry
Core Tip	Human epidermal growth factor receptor 2 (HER2) detection in mixed gastric carcinoma displays high heterogeneity; a standard detection of HER2 in mixed gastric cancer is needed to better guide therapeutic interventions. In this study, we utilized immunohistochemistry (IHC) to detect HER2 protein expression and fluorescence in situ hybridization (FISH) to detect HER2 amplification. We classified HER2 positive staining range by IHC as extensive, partial, and focal types, and defined HER2 amplification patterns by FISH as cluster, large granule, dot, and HH-17 categories. Clinical therapeutic findings of our patients validated our approaches for assessing the level of HER2 amplification and protein expression, and proved that these parameters are clinically useful.
Publish Date	2015-04-20 15:10
Citation	Wang YK, Chen Z, Yun T, Li CY, Jiang B, Lv XX, Chu GH, Wang SN, Yan H, Shi LF. Human epidermal growth factor receptor 2 expression in mixed gastric carcinoma. World J Gastroenterol 2015; 21(15): 4680-4687
URL	http://www.wjgnet.com/1007-9327/full/v21/i15/4680.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i15.4680

Full Article (PDF)	WJG-21-4680.pdf
Full Article (Word)	WJG-21-4680.doc
Manuscript File	15306-Review.doc
Answering Reviewers	15306-Answering reviewers.pdf
Biostatistics Review Certificate	15306-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	15306-Conflict-of-interest statement.pdf
Copyright License Agreement	15306-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	15306-Institutional review board statement.pdf
Peer-review Report	15306-Peer-review(s).pdf
Scientific Misconduct Check	15306-Scientific misconduct check.pdf
Scientific Editor Work List	15306-Scientific editor work list.pdf