Publication Name	World Journal of Gastroenterology
Manuscript ID	15334
Country	China

Received	2014-11-22 14:36
Peer-Review Started	2014-11-23 13:51
To Make the First Decision	2014-12-26 13:30
Return for Revision	2015-01-05 10:00
Revised	2015-01-21 11:14
Second Decision	2015-02-10 21:25
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-02-11 15:49
Articles in Press	2015-02-11 16:20
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-03-10 01:58
Typeset the Manuscript	2015-04-29 09:29
Publish the Manuscript Online	2015-05-18 17:02

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Cell Biology
Manuscript Type	Basic Study
Article Title	Downregulation of rho-associated protein kinase 1 by miR-124 in colorectal cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Zuo-Wu Xi, Shi-Yong Xin, Li-Qing Zhou, Hai-Xin Yuan, Qian Wang and Kai-Xuan Chen
Funding Agency and Grant Number
Corresponding Author	Kai-Xuan Chen, MD, Department of Anorectal Surgery, Henan province Hospital of Traditional Chinese Medicine (Second Affiliated Hospital of Henan University of traditional Chinese medicine), Dongfeng Road No. 6, Zhengzhou 450002, Henan Province, China. doctkxchen@163.com
Key Words	Cell invasion; Colorectal cancer; miR-124; Rho-associated protein kinase
Core Tip	miR-124 inhibits neoplastic transformation, cell proliferation, and metastasis, and downregulates rho-associated protein kinase (ROCK)1 in some cancers. In this study, we investigated the roles and interactions of ROCK1 and miR-124 in human colorectal cancer (CRC). miR-124 promoted cell hyperplasia and contributed to invasion, but downregulated ROCK1 in CRC. ROCK1 and miR-124 may play important roles in CRC.
Publish Date	2015-05-18 17:02
Citation	Xi ZW, Xin SY, Zhou LQ, Yuan HX, Wang Q, Chen KX. Downregulation of rho-associated protein kinase 1 by miR-124 in colorectal cancer. World J Gastroenterol 2015; 21(18): 5454-5464
URL	http://www.wjgnet.com/1007-9327/full/v21/i18/5454.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i18.5454

Full Article (PDF)	WJG-21-5454.pdf
Full Article (Word)	WJG-21-5454.doc
Manuscript File	15334-Review.doc
Answering Reviewers	15334-Answering reviewers.pdf
Copyright License Agreement	15334-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	15334-Language certificate.PDF
Peer-review Report	15334-Peer-review(s).pdf
Scientific Misconduct Check	15334-Scientific misconduct check.pdf
Scientific Editor Work List	15334-Scientific editor work list.pdf