Publication Name	World Journal of Gastroenterology
Manuscript ID	15359
Country	China

Received	2014-11-24 08:48
Peer-Review Started	2014-11-24 10:13
To Make the First Decision	2015-01-08 16:56
Return for Revision	2015-01-13 08:40
Revised	2015-02-09 10:27
Second Decision	2015-03-09 14:21
Accepted by Journal Editor-in-Chief	2015-03-09 16:50
Accepted by Executive Editor-in-Chief	2015-03-12 16:20
Articles in Press	2015-03-12 16:45
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-03-24 22:06
Typeset the Manuscript	2015-05-22 10:00
Publish the Manuscript Online	2015-06-11 10:11

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Basic Study
Article Title	Alternative splicing of VEGFA, APP and NUMB genes in colorectal cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Yi-Jun Zhao, Hua-Zhong Han, Yong Liang, Chen-Zhang Shi, Qing-Chao Zhu and Jun Yang
Funding Agency and Grant Number
Corresponding Author	Jun Yang, MD, Associate Professor, Department of Surgery, Shanghai Jiao Tong University, Affiliated Sixth People’s Hospital, No. 600 Yishan Road, Shanghai 200233, China. yangjun_sh@163.com
Key Words	Alternative splicing; Amyloid beta precursor protein; Colorectal cancer; Numb homolog; Vascular endothelial growth factor A
Core Tip	This study was undertaken to investigate the effect of alternative splicing of vascular endothelial growth factor A (VEGFA), amyloid beta precursor protein (APP), and Numb homolog (NUMB) genes in colorectal cancer (CRC). We demonstrated that these genes and their alternative splice variants were different in CRC tissues and matched adjacent normal tissues using quantitative reverse transcriptase PCR and PCR-restriction fragment length polymorphism analyses. We conclude that alternative splicing of VEGFA, APP, and NUMB may be associated with the diagnosis, prognosis, and treatment of CRC. This study may help in understanding the relationship between alternative splicing and CRC.
Publish Date	2015-06-11 10:11
Citation	Zhao YJ, Han HZ, Liang Y, Shi CZ, Zhu QC, Yang J. Alternative splicing of VEGFA, APP and NUMB genes in colorectal cancer. World J Gastroenterol 2015; 21(21): 6550-6560
URL	http://www.wjgnet.com/1007-9327/full/v21/i21/6550.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i21.6550

Full Article (PDF)	WJG-21-6550.pdf
Full Article (Word)	WJG-21-6550.doc
Manuscript File	15359-Review.doc
Answering Reviewers	15359-Answering reviewers.pdf
Audio Core Tip	15359-Audio core tip.mp3
Biostatistics Review Certificate	15359-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	15359-Conflict-of-interest statement.pdf
Copyright License Agreement	15359-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	15359-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	15359-Language certificate.PDF
Peer-review Report	15359-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	15359-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	15359-Scientific misconduct check.pdf
Scientific Editor Work List	15359-Scientific editor work list.pdf