Publication Name	World Journal of Gastroenterology
Manuscript ID	15378
Country	United States

Received	2014-11-24 19:14
Peer-Review Started	2014-11-25 10:42
To Make the First Decision	2014-12-11 20:23
Return for Revision	2014-12-16 09:00
Revised	2014-12-24 10:38
Second Decision	2015-01-31 09:26
Accepted by Journal Editor-in-Chief	2015-02-02 07:55
Accepted by Executive Editor-in-Chief	2015-02-05 17:08
Articles in Press	2015-02-05 17:39
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-03-18 16:32
Publish the Manuscript Online	2015-03-30 14:23

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Management of hepatocellular carcinoma with portal vein thrombosis
Manuscript Source	Invited Manuscript
All Author List	Matthew Quirk, Yun Hwan Kim, Sammy Saab and Edward Wolfgang Lee
Funding Agency and Grant Number
Corresponding Author	Edward Wolfgang Lee, MD, PhD, Department of Radiology, Division of Interventional Radiology, Ronald Reagan Medical Center at UCLA, David Geffen School of Medicine at UCLA, 757 Westwood Plaza, Suite 2125, Los Angeles, CA 90095-743730, United States. edwardlee@mednet.ucla.edu
Key Words	Hepatocellular carcinoma; Portal vein thrombosis; Yttrium 90; Selective internal radiation therapy; Management
Core Tip	Management for hepatocellular carcinoma (HCC) with portal vein thrombosis (PVT) is more challenging and limited than for HCC without PVT. Currently, liver transplantation is generally contraindicated and surgical resection with curative intent is contro?versial. Systemic chemotherapy with sorafenib has been shown to modestly prolong survival. Transarterial chemoembolization has traditionally been considered to be contraindicated due to its high embolic effect causing hepatic necrosis and worsening liver dysfunction. External radiation therapy is limited by the sensitivity of the liver to radiation toxicity. In this review, these treatment options are comprehensively presented, along with a relatively new modality in the treatment of HCC, selective internal radiation therapy with yttrium-90.
Publish Date	2015-03-30 14:23
Citation	Quirk M, Kim YH, Saab S, Lee EW. Management of hepatocellular carcinoma with portal vein thrombosis. World J Gastroenterol 2015; 21(12): 3462-3471
URL	http://www.wjgnet.com/1007-9327/full/v21/i12/3462.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i12.3462

Full Article (PDF)	WJG-21-3462.pdf
Full Article (Word)	WJG-21-3462.doc
Manuscript File	15378-Review.docx
Answering Reviewers	15378-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	15378-Conflict-of-Interest-Statement.pdf
Copyright License Agreement	15378-Copyright assignment.pdf
Peer-review Report	15378-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	15378-Journal Editor-in-Chief's Review Report.docx
Scientific Misconduct Check	15378-Scientific misconduct check.pdf
Scientific Editor Work List	15378-Scientific editor work list.pdf