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3/30/2015 5:46:00 PM | Browse: 683 | Download: 677
Publication Name World Journal of Gastroenterology
Manuscript ID 15378
Country/Territory United States
2014-11-24 19:14
Peer-Review Started
2014-11-25 10:42
To Make the First Decision
2014-12-11 20:23
Return for Revision
2014-12-16 09:00
2014-12-24 10:38
Second Decision
2015-01-31 09:26
Accepted by Journal Editor-in-Chief
2015-02-02 07:55
Accepted by Company Editor-in-Chief
2015-02-05 17:08
Articles in Press
2015-02-05 17:39
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-03-18 16:32
Publish the Manuscript Online
2015-03-30 14:23
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Review
Article Title Management of hepatocellular carcinoma with portal vein thrombosis
Manuscript Source Invited Manuscript
All Author List Matthew Quirk, Yun Hwan Kim, Sammy Saab and Edward Wolfgang Lee
Funding Agency and Grant Number
Corresponding Author Edward Wolfgang Lee, MD, PhD, Department of Radiology, Division of Interventional Radiology, Ronald Reagan Medical Center at UCLA, David Geffen School of Medicine at UCLA, 757 Westwood Plaza, Suite 2125, Los Angeles, CA 90095-743730, United States. edwardlee@mednet.ucla.edu
Key Words Hepatocellular carcinoma; Portal vein thrombosis; Yttrium 90; Selective internal radiation therapy; Management
Core Tip Management for hepatocellular carcinoma (HCC) with portal vein thrombosis (PVT) is more challenging and limited than for HCC without PVT. Currently, liver transplantation is generally contraindicated and surgical resection with curative intent is contro?versial. Systemic chemotherapy with sorafenib has been shown to modestly prolong survival. Transarterial chemoembolization has traditionally been considered to be contraindicated due to its high embolic effect causing hepatic necrosis and worsening liver dysfunction. External radiation therapy is limited by the sensitivity of the liver to radiation toxicity. In this review, these treatment options are comprehensively presented, along with a relatively new modality in the treatment of HCC, selective internal radiation therapy with yttrium-90.
Publish Date 2015-03-30 14:23
Citation Quirk M, Kim YH, Saab S, Lee EW. Management of hepatocellular carcinoma with portal vein thrombosis. World J Gastroenterol 2015; 21(12): 3462-3471
URL http://www.wjgnet.com/1007-9327/full/v21/i12/3462.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i12.3462
Full Article (PDF) WJG-21-3462.pdf
Full Article (Word) WJG-21-3462.doc
Manuscript File 15378-Review.docx
Answering Reviewers 15378-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form 15378-Conflict-of-Interest-Statement.pdf
Copyright License Agreement 15378-Copyright assignment.pdf
Peer-review Report 15378-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 15378-Journal Editor-in-Chief's Review Report.docx
Scientific Misconduct Check 15378-Scientific misconduct check.pdf
Scientific Editor Work List 15378-Scientific editor work list.pdf