Publication Name	World Journal of Gastroenterology
Manuscript ID	15379
Country	South Korea

Received	2014-11-24 19:26
Peer-Review Started	2014-11-25 10:39
To Make the First Decision	2014-12-26 13:24
Return for Revision	2014-12-31 09:07
Revised	2015-01-02 14:04
Second Decision	2015-01-31 09:27
Accepted by Journal Editor-in-Chief	2015-01-31 18:32
Accepted by Executive Editor-in-Chief	2015-02-05 17:09
Articles in Press	2015-02-05 17:39
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-02-08 18:55
Typeset the Manuscript	2015-03-23 11:24
Publish the Manuscript Online	2015-04-07 17:13

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Hepatic artery infusion chemotherapy for advanced hepatocellular carcinoma
Manuscript Source	Invited Manuscript
All Author List	Myeong Jun Song
Funding Agency and Grant Number
Corresponding Author	Myeong Jun Song, MD, PhD, Division of Hepatology, Department of Internal Medicine, Daejeon St. Mary’s Hospital, College of Medicine, the Catholic University of Korea, Daeheung-ro 64, Jung-gu, Daejeon 301-723, South Korea. mjsong95@gmail.com
Key Words	Hepatocellular carcinoma; Advanced stage hepatocellular carcinoma; Sorafenib; Hepatic arterial infusion chemotherapy; Treatment efficacy
Core Tip	Sorafenib is the standard of treatment for advanced hepatocellular carcinoma (HCC). However, the suitability of sorafenib is limited by its low response rates, and unsuitability for patients with poor liver function. Therefore, other treatment modalities are required. Hepatic arterial infusion chemotherapy (HAIC) has the advantages of delivering high levels of chemotherapeutic drugs directly into tumor-associated hepatic arterial branches and repeat injections are relatively simple to carry out. Thus the local therapeutic level is increased and systemic adverse effects are decreased. In the future, HAIC may be a promising treatment strategy for the management of advanced HCC.
Publish Date	2015-04-07 17:13
Citation	Song MJ. Hepatic artery infusion chemotherapy for advanced hepatocellular carcinoma. World J Gastroenterol 2015; 21(13): 3843-3849
URL	http://www.wjgnet.com/1007-9327/full/v21/i13/3843.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i13.3843

Full Article (PDF)	WJG-21-3843.pdf
Full Article (Word)	WJG-21-3843.doc
Manuscript File	15379-Review.doc
Answering Reviewers	15379-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	15379-Conflict-of-interest statement.pdf
Copyright License Agreement	15379-Conflict-of-interest statement.pdf
Peer-review Report	15379-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	15379-Journal Editor-in-Chief's Review Report.pdf
Scientific Misconduct Check	15379-Scientific misconduct check.pdf
Scientific Editor Work List	15379-Scientific editor work list.pdf