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Articles Published Processes
6/11/2015 10:11:00 AM | Browse: 1020 | Download: 1658
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Received |
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2014-11-27 10:23 |
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Peer-Review Started |
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2014-11-27 14:18 |
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To Make the First Decision |
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2014-12-11 20:23 |
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Return for Revision |
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2014-12-16 09:01 |
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Revised |
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2015-01-23 15:43 |
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Second Decision |
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2015-03-09 14:22 |
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Accepted by Journal Editor-in-Chief |
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2015-03-09 17:52 |
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Accepted by Company Editor-in-Chief |
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2015-03-12 16:25 |
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Articles in Press |
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2015-03-12 16:45 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2015-04-02 20:46 |
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Typeset the Manuscript |
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2015-05-24 14:27 |
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Publish the Manuscript Online |
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2015-06-11 10:11 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Chemistry, Medicinal |
| Manuscript Type |
Basic Study |
| Article Title |
Effect of resveratrol on Treg/Th17 signaling and ulcerative colitis treatment in mice
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jun Yao, Cheng Wei, Jian-Yao Wang, Ru Zhang, Ying-Xue Li and Li-Sheng Wang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Outstanding Doctoral Thesis Support Project of Guangdong Province |
85514045 |
| Technical Research and Development Project of Shenzhen |
JCYJ20130402092657774 |
| Medical Research Foundation of Guangdong Province |
B2013347 |
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| Corresponding Author |
Dr. Li-Sheng Wang, Department of Gastroenterology, Jinan University of Medical Sciences, Shenzhen Municipal People’s Hospital, 1017 East Gate Road, Shenzhen, 518020, Guangdong Province, China. wangls168@163.com |
| Key Words |
Hypoxia inducible factor-; Mammalian target of rapamycin; Resveratrol; Th17 cells; Treg cells; Ulcerative colitis |
| Core Tip |
Ulcerative colitis is an inflammatory bowel disease manifested by recurrent chronic diarrhea, bloody and mucous stools, and abdominal pain. The etiology and pathogenesis are not clear. Resveratrol is a natural and biologically active polyphenol with a variety of anti-inflammatory and antioxidant functions, which are beneficial to human health. This study aimed determine the therapeutic efficacy of resveratrol on ulcerative colitis and its underlying mechanisms. The results demonstrate that the therapeutic efficacy of resveratrol is dose dependent and closely associated with the regulation of Treg/Th17 balance and the hypoxia inducible factor-1?/mammalian target of rapamycin signaling pathway. |
| Publish Date |
2015-06-11 10:11 |
| Citation |
Yao J, Wei C, Wang JY, Zhang R, Li YX, Wang LS. Effect of resveratrol on Treg/Th17 signaling and ulcerative colitis treatment in mice. World J Gastroenterol 2015; 21(21): 6572-6581 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i21/6572.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i21.6572 |
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