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4/30/2015 2:11:00 PM | Browse: 650 | Download: 778
Publication Name World Journal of Gastroenterology
Manuscript ID 15462
Country/Territory Italy
2014-11-27 09:18
Peer-Review Started
2014-11-27 10:04
To Make the First Decision
2014-12-11 20:23
Return for Revision
2014-12-16 09:02
2014-12-19 21:33
Second Decision
2015-01-08 13:19
Accepted by Journal Editor-in-Chief
2015-01-09 15:37
Accepted by Company Editor-in-Chief
2015-01-16 17:36
Articles in Press
2015-01-16 18:20
Publication Fee Transferred
Edit the Manuscript by Language Editor
2015-01-21 17:56
Typeset the Manuscript
2015-04-08 09:37
Publish the Manuscript Online
2015-04-20 15:10
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Prospective Study
Article Title Pancreatic fat and β-cell function in overweight/obese children with nonalcoholic fatty liver disease
Manuscript Source Invited Manuscript
All Author List Lucia Pacifico, Michele Di Martino, Caterina Anania, Gian Marco Andreoli, Mario Bezzi, Carlo Catalano and Claudio Chiesa
Funding Agency and Grant Number
Funding Agency Grant Number
Sapienza University of Rome (Progetti di Ricerca Universitaria) 2011-2012
Corresponding author Claudio Chiesa, MD, Institute of Translational Pharmacology, National Research Council, Via Fosso del Cavaliere 100, 00133 Rome, Italy. claudio.chiesa@ift.cnr.it
Key Words Nonalcoholic fatty liver disease; Pancreatic fat; Visceral fat; Beta-cell function; Children
Core Tip Recent studies in children demonstrate that the prevalence of prediabetes increases with the increase in hepatic fat content,and that fatty liver plays a central role in the impairment of liver, muscle,and adipose insulin sensitivity. Pancreatic fat has been identified as a novel obesity-related fat depot, which may contribute to the development of β-cell dysfunction. This study demonstrates that in overweight/obese children with nonalcoholic fatty liver disease (NAFLD), pancreatic fat is increased compared with those without NAFLD. However, only liver fat is independently related to prediabetes. Early intervention during childhood to recognize NAFLD might be a crucial step in averting an unfavorable metabolic phenotype.
Publish Date 2015-04-20 15:10
Citation Pacifico L, Di Martino M, Anania C, Andreoli GM, Bezzi M, Catalano C, Chiesa C. Pancreatic fat and β-cell function in overweight/obese children with nonalcoholic fatty liver disease. World J Gastroenterol 2015; 21(15): 4688-4695
Url http://www.wjgnet.com/1007-9327/full/v21/i15/4688.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i15.4688
Full Article (PDF) WJG-21-4688.pdf
Full Article (Word) WJG-21-4688.doc
Manuscript File 15462-Review.doc
Answering Reviewers 15462-Answering reviewers.pdf
Biostatistics Review Certificate 15462-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 15462-Conflict-of-interest statement.pdf
Copyright License Agreement 15462-Copyright assignment.pdf
Data Sharing Statement 15462-Data sharing statement.pdf
Institutional Review Board Approval Form or Document 15462-Institutional Review Board (IRB) statement.pdf
Non-Native Speakers of English Editing Certificate 15462-Language certificate.pdf
Peer-review Report 15462-Peer-review(s).pdf
Scientific Misconduct Check 15462-CorssCheck.jpg
Scientific Editor Work List 15462-Scientific editor work list.pdf