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Articles Published Processes
4/30/2015 2:11:00 PM | Browse: 1086 | Download: 1651
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Received |
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2014-11-27 09:18 |
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Peer-Review Started |
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2014-11-27 10:04 |
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To Make the First Decision |
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2014-12-11 20:23 |
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Return for Revision |
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2014-12-16 09:02 |
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Revised |
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2014-12-19 21:33 |
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Second Decision |
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2015-01-08 13:19 |
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Accepted by Journal Editor-in-Chief |
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2015-01-09 15:37 |
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Accepted by Executive Editor-in-Chief |
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2015-01-16 17:36 |
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Articles in Press |
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2015-01-16 18:20 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2015-01-21 17:56 |
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Typeset the Manuscript |
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2015-04-08 09:37 |
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Publish the Manuscript Online |
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2015-04-20 15:10 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Prospective Study |
| Article Title |
Pancreatic fat and β-cell function in overweight/obese children with nonalcoholic fatty liver disease
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Lucia Pacifico, Michele Di Martino, Caterina Anania, Gian Marco Andreoli, Mario Bezzi, Carlo Catalano and Claudio Chiesa |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Sapienza University of Rome (Progetti di Ricerca Universitaria) |
2011-2012 |
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| Corresponding Author |
Claudio Chiesa, MD, Institute of Translational Pharmacology, National Research Council, Via Fosso del Cavaliere 100, 00133 Rome, Italy. claudio.chiesa@ift.cnr.it |
| Key Words |
Nonalcoholic fatty liver disease; Pancreatic fat; Visceral fat; Beta-cell function; Children |
| Core Tip |
Recent studies in children demonstrate that the prevalence of prediabetes increases with the increase in hepatic fat content,and that fatty liver plays a central role in the impairment of liver, muscle,and adipose insulin sensitivity. Pancreatic fat has been identified as a novel obesity-related fat depot, which may contribute to the development of β-cell dysfunction. This study demonstrates that in overweight/obese children with nonalcoholic fatty liver disease (NAFLD), pancreatic fat is increased compared with those without NAFLD. However, only liver fat is independently related to prediabetes. Early intervention during childhood to recognize NAFLD might be a crucial step in averting an unfavorable metabolic phenotype. |
| Publish Date |
2015-04-20 15:10 |
| Citation |
Pacifico L, Di Martino M, Anania C, Andreoli GM, Bezzi M, Catalano C, Chiesa C. Pancreatic fat and β-cell function in overweight/obese children with nonalcoholic fatty liver disease. World J Gastroenterol 2015; 21(15): 4688-4695 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i15/4688.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i15.4688 |
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