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Articles Published Processes
5/30/2015 1:35:00 PM | Browse: 733 | Download: 1265
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Received |
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2014-11-27 09:16 |
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Peer-Review Started |
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2014-11-27 10:01 |
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To Make the First Decision |
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2014-12-26 13:24 |
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Return for Revision |
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2014-12-31 09:11 |
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Revised |
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2015-01-19 15:39 |
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Second Decision |
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2015-02-11 22:58 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2015-02-13 10:29 |
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Articles in Press |
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2015-02-13 11:28 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2015-03-09 17:57 |
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Typeset the Manuscript |
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2015-05-13 19:44 |
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Publish the Manuscript Online |
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2015-05-30 13:32 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Insights into glycan biosynthesis in chemically-induced hepatocellular carcinoma in rats: A glycomic analysis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Amr Amin, Asma Bashir, Nazar Zaki, Diane McCarthy, Sanjida Ahmed and Mohamed Lotfy |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Research Foundation Grant |
UIRCA 2012-21832 to A. Amin |
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| Corresponding Author |
Amr Amin, PhD, Professor, Department of Biology, College of Science, UAE University, University Street, Al-Ain 15551, United Arab Emirates. a.amin@uaeu.ac.ae |
| Key Words |
Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry; Hepatocellular carcinoma; Glycomics; Biosynthetic pathways |
| Core Tip |
Hepatocellular carcinoma (HCC) is a leading cause of cancer death worldwide, yet it is still poorly diagnosed. Glycans are emerging as sensitive and simple biomarkers of various malignant diseases. Utilizing the cutting-edge N-glycomic analysis, we identified 5 glycans that were significantly different between normal and tumor-bearing rats. An increase in high-mannose structures in HCC rats was observed compared to normal rats. HCC rats showed an increase in both tumor-associated carbohydrates and branched glycans. The changes in glycans correlated with glycan flow changes reported in the glycan biosynthetic pathway, which indicates the importance of enzyme activities involved in glycan synthesis at different subcellular localizations. |
| Publish Date |
2015-05-30 13:32 |
| Citation |
Amin A, Bashir A, Zaki N, McCarthy D, Ahmed S, Lotfy M. Insights into glycan biosynthesis in chemically-induced hepatocellular carcinoma in rats: A glycomic analysis. World J Gastroenterol 2015; 21(20): 6167-6179 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i20/6167.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i20.6167 |
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