| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
|
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
MicroRNA-185-5p mediates the regulation of SREBP2 expression by hepatitis C virus core protein
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Min Li, Qi Wang, Shun-Ai Liu, Jin-Qian Zhang, Wei Ju, Min Quan, Sheng-Hu Feng, Jin-Ling Dong, Ping Gao and Jun Cheng |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Medical Specialty Development Projects of Beijing Municipal Administration of Hospitals |
ZYLX201402 |
| Ministry of Education of The People’s Republic of China |
20121107110012 |
| Beijing Municipal Commission of Education |
11320016 |
| Collaborative Innovation Center of Infectious Diseases and Beijing Key Laboratory of Emerging Infectious Diseases, Beijing, China |
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| Corresponding Author |
Jun Cheng, MD, PhD, EMBA, Professor, Beijing Ditan Hospital, Teaching Hospital of Peking University, 8 East Jingshun St., Beijing 100015, China. jun.cheng.ditan@gmail.com |
| Key Words |
Steatosis; Hepatitis C virus core protein; Cholesterol; Sterol response element binding proteins; miR-185-5p |
| Core Tip |
In this study, we investigated the regulation relationship between hepatitis C virus (HCV) core protein and sterol regulatory element binding protein 2 (SREBP2). The miR-185-5p was confirmed in the regulation of SERBP2 expression, and it was the target for HCV core protein. The regulation relationship between HCV core, microRNA-185-5p and SREBP2 was established at transcriptional, post-transcriptional, and translational levels. |
| Publish Date |
2015-04-20 15:10 |
| Citation |
Li M, Wang Q, Liu SA, Zhang JQ, Ju W, Quan M, Feng SH, Dong JL, Gao P, Cheng J. MicroRNA-185-5p mediates regulation of SREBP2 expression by hepatitis C virus core protein. World J Gastroenterol 2015; 21(15): 4517-4525 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i15/4517.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i15.4517 |
