Publication Name	World Journal of Nephrology
Manuscript ID	15524
Country	Spain

Received	2014-11-28 08:26
Peer-Review Started	2014-11-29 13:19
To Make the First Decision	2014-12-12 17:32
Return for Revision	2014-12-18 12:07
Revised	2015-01-18 19:37
Second Decision	2015-01-28 12:07
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-02-09 09:45
Articles in Press	2015-02-09 09:45
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-04-07 12:07
Publish the Manuscript Online	2015-05-08 14:17

ISSN	2220-6124 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Urology & Nephrology
Manuscript Type	Minireviews
Article Title	Is there a role for systemic targeted therapy after surgical treatment for metastases of renal cell carcinoma?
Manuscript Source	Invited Manuscript
All Author List	Adrian Husillos Alonso, Manuel Carbonero García and Carmen González Enguita
Funding Agency and Grant Number
Corresponding Author	Adrian Husillos Alonso, MD, Servicio de Urología, Hospital Universitario Infanta Elena (HUIE), Avda. Reyes Católicos 21, 28340 Valdemoro, Madrid, Spain. adrian.husillos@idcsalud.es
Key Words	Metastatic renal cell carcinoma; Targeted therapy: Metastasectomy; Surgery; Adjuvant treatment
Core Tip	We have made a search in Pubmed database looking for evidence to support adjuvant systemic therapy after metastasectomy in metastatic renal cell carcinoma. As far as we know, evidence is low and it’s based in case reports and small series of patients. Despite the limitations and high risk of bias, promising results and cases with long-term survival with this approach have been described. Two ongoing clinical trials may answer the question that concerns us.
Publish Date	2015-05-08 14:17
Citation	Husillos Alonso A, Carbonero García M, González Enguita C. Is there a role for systemic targeted therapy after surgical treatment for metastases of renal cell carcinoma? World J Nephrol 2015; 4(2): 254-262
URL	http://www.wjgnet.com/2220-6124/full/v4/i2/254.htm
DOI	http://dx.doi.org/10.5527/wjn.v4.i2.254

Full Article (PDF)	WJN-4-254.pdf
Full Article (Word)	WJN-4-254.doc
Manuscript File	15524-Review.doc
Answering Reviewers	15524-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	15524-Conflict-of-interest statement.pdf
Copyright License Agreement	15524-Copyright assignment.pdf
Peer-review Report	15524-Peer-review(s).pdf
Scientific Misconduct Check	15524-Scientific misconduct check.pdf
Scientific Editor Work List	15524-Scientific editor work list.pdf