Publication Name	World Journal of Gastroenterology
Manuscript ID	1553
Country	China

Received	2012-12-19 16:27
Peer-Review Started	2012-12-20 14:39
To Make the First Decision	2013-02-01 21:47
Return for Revision	2013-02-17 15:20
Revised	2013-04-05 16:32
Second Decision	2013-06-06 09:17
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-06-06 12:36
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-06-26 17:46
Publish the Manuscript Online	2013-07-06 17:46

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Clinical significance of melatonin concentrations in predicting the severity of acute pancreatitis
Manuscript Source	Invited Manuscript
All Author List	Yin Jin, Chun-Jing Lin, Le-Mei Dong, Meng-Jun Chen, Qiong Zhou and Jian-Sheng Wu
Funding Agency and Grant Number	Funding Agency Grant Number Wenzhou Municipal Science and Technology Commission Major Projects Funds 20090006
Corresponding Author	Jian-Sheng Wu, Professor of Medicine, Department of Gastroenterology, First Affiliated Hospital of Wenzhou Medical College, No. 2 Xuefu Road, Lucheng District, Wenzhou 325000, Zhejiang Province, China. wzwujs@163.com
Key Words	Pancreatitis; Melatonin concentrations; Predict; Cutoff; Bedside index for severity in acute pancreatitis; Acute physiology and chronic health evaluation Ⅱ
Core Tip	It is important to assess the severity and changes in a patient’s condition in a timely and accurate manner. Thus, a comprehensive treatment plan for acute pancreatitis patients is critical. Melatonin plays a protective role in the early course of human acute pancreatitis, and melatonin concentration variations are closely related to the severity of acute pancreatitis and the bedside index for severity in acute pancreatitis score. We can determine the severity of disease in the clinic more objectively, accurately and rapidly by measuring the levels of serum melatonin than by using the standard scoring systems. When the serum concentration of melatonin is below 28.74 ng/L, it is possible that acute pancreatitis patients will develop severe acute pancreatitis.
Publish Date	2013-07-06 17:46
Citation	Jin Y, Lin CJ, Dong LM, Chen MJ, Zhou Q, Wu JS. Clinical significance of melatonin concentrations in predicting the severity of acute pancreatitis. World J Gastroenterol 2013; 19(25): 4066-4071
URL	http://www.wjgnet.com/1007-9327/full/v19/i25/4066.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i25.4066

Full Article (PDF)	WJG-19-4066.pdf
Manuscript File	1553-Review.docx
Answering Reviewers	1553-Answering reviewers.doc
Copyright License Agreement	1553-Copyright assignment.doc
Non-Native Speakers of English Editing Certificate	1553-Language certificate.pdf
Peer-review Report	1553-Peer review(s).pdf
Scientific Editor Work List	1553-Scientific editor work list.doc