Publication Name	World Journal of Hepatology
Manuscript ID	15538
Country	Italy

Received	2014-11-28 18:57
Peer-Review Started	2014-11-29 13:15
To Make the First Decision	2015-01-08 14:01
Return for Revision	2015-01-14 13:58
Revised	2015-01-20 16:29
Second Decision	2015-05-15 17:40
Accepted by Journal Editor-in-Chief	2015-05-15 18:36
Accepted by Executive Editor-in-Chief	2015-05-27 15:08
Articles in Press	2015-05-27 15:23
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-06-06 14:09
Publish the Manuscript Online	2015-06-29 17:40

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Radiology, Nuclear Medicine & Medical Imaging
Manuscript Type	Observational Study
Article Title	Downstaging disease in patients with hepatocellular carcinoma outside up-to-seven criteria: Strategies using degradable starch microspheres transcatheter arterial chemo-embolization
Manuscript Source	Invited Manuscript
All Author List	Antonio Orlacchio, Fabrizio Chegai, Stefano Merolla, Simona Francioso, Costantino Del Giudice, Mario Angelico, Giuseppe Tisone and Giovanni Simonetti
Funding Agency and Grant Number
Corresponding Author	Antonio Orlacchio, MD, Department of Diagnostic and Molecular Imaging, Radiation Therapy and Interventional Radiology, University Hospital Tor Vergata, Viale Oxford 81, 00133 Rome, Italy. aorlacchio@uniroma2.it
Key Words	Hepatocellular carcinoma; Transcatheter arterial chemoembolization; Liver transplantation; Degradable starch microspheres; New-Milan-criteria; Recurrence-free survival; Locoregional therapies
Core Tip	Liver transplantation (LT) is the standard of care for select patients with hepatocellular carcinoma (HCC) and cirrhosis and recently more transplant centers use the new Milan criteria to assess the candidacy of HCC patients for LT. This manuscript reports a preliminary experience on the HCC treatment in liver transplant candidates without new-Milan-criteria, using a new technique of transcatheter arterial chemo-embolization with degradable starch microspheres transcatheter arterial chemoembolization (DSM-TACE). Providing a temporary embolization DSM-TACE allows to treat more patients with an impaired liver function reducing toxicity due to standard arterial embolization. Moreover good down-staging rates after repeated DSM-TACE were successfully achieved.
Publish Date	2015-06-29 17:40
Citation	Orlacchio A, Chegai F, Merolla S, Francioso S, Del Giudice C, Angelico M, Tisone G, Simonetti G. Downstaging disease in patients with hepatocellular carcinoma outside up-to-seven criteria: Strategies using degradable starch microspheres trans­catheter arterial chemo-embolization. World J Hepatol 2015; 7(12): 1694-1700
URL	http://www.wjgnet.com/1948-5182/full/v7/i12/1694.htm
DOI	http://dx.doi.org/10.4254/wjh.v7.i12.1694

Full Article (PDF)	WJH-7-1694.pdf
Full Article (Word)	WJH-7-1694.doc
Manuscript File	15538-Review.docx
Answering Reviewers	15538-Answering reviewers.pdf
Audio Core Tip	15538-Audio core tip.m4a
Biostatistics Review Certificate	15538-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	15538-Conflict-of-interest statetement.pdf
Copyright License Agreement	15538-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	15538-Institutional review board statement.pdf
Peer-review Report	15538-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	15538-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	15538-Scientific misconduct check.pdf
Scientific Editor Work List	15538-Scientific editor work list.pdf