Publication Name	World Journal of Hepatology
Manuscript ID	15543
Country	China

Received	2014-11-29 14:53
Peer-Review Started	2014-11-29 17:28
First Decision by Editorial Office Director
Return for Revision	2015-01-14 14:07
Revised	2015-01-19 23:41
Publication Fee Transferred
Second Decision by Editor	2015-03-09 09:04
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2015-03-18 16:45
Articles in Press	2015-03-18 16:45
Edit the Manuscript by Language Editor	2015-03-23 14:11
Typeset the Manuscript	2015-05-11 19:04
Publish the Manuscript Online	2015-05-20 16:43

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Key role of hepatitis B virus mutation in chronic hepatitis B development to hepatocellular carcinoma
Manuscript Source	Invited Manuscript
All Author List	Xin Zhang and Hui-Guo Ding
Funding Agency and Grant Number	Funding Agency Grant Number Capital Science and Technology Development Foundation, Major Projects on Infectious Disease 2012ZX1002-008-05 High-Level Talent Academic Leader Training Program 2011-2-19 Capital Science and Tchnology Development Fund 2014-1-2181
Corresponding Author	Hui-Guo Ding, MD, PhD, Director of Gastroenterology and Hepatology, Department of Gastroenterology and Hepatology, Beijing You’an Hospital affiliated with Capital Medical University, Fengtai District, Beijing 100069, China. dinghuiguo@medmail.com.cn
Key Words	Hepatitis B virus; Mutations; Hepatocellular carcinoma; Carcinogenesis; Chronic hepatitis B
Core Tip	This mini review fully describes the relationship between hepatitis B virus (HBV) genome mutations in different regions with liver disease progression and development to hepatocellular carcinoma (HCC) according to the recent data of mutations in chronic hepatitis B patients. Accordingly, the HBV mutations, either in the preS or PreC or/and core promoter region, are significantly associated with HCC and could be regarded as a biomarker to predict the occurrence of HCC.
Publish Date	2015-05-20 16:43
Citation	Zhang X, Ding HG. Key role of hepatitis B virus mutation in chronic hepatitis B development to hepatocellular carcinoma. World J Hepatol 2015; 7(9): 1282-1286
URL	http://www.wjgnet.com/1948-5182/full/v7/i9/1282.htm
DOI	http://dx.doi.org/10.4254/wjh.v7.i9.1282

Full Article (PDF)	WJH-7-1282.pdf
Full Article (Word)	WJH-7-1282.doc
Manuscript File	15543-Review.docx
Answering Reviewers	15543-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	15543-Conflict-of-interest statement.pdf
Copyright License Agreement	15543-Copyright assignment.pdf
Peer-review Report	15543-Peer-review(s).pdf
Scientific Misconduct Check	15543-Scientific misconduct check.pdf
Scientific Editor Work List	15543-Scientific editor work list.pdf