Publication Name	World Journal of Clinical Cases
Manuscript ID	15546
Country

Received	2014-11-29 14:45
Peer-Review Started	2014-11-29 17:18
To Make the First Decision	2014-12-12 17:32
Return for Revision	2014-12-18 11:46
Revised	2014-12-23 17:27
Second Decision	2015-05-29 15:21
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-06-08 15:56
Articles in Press	2015-06-08 16:26
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-08-06 09:35
Publish the Manuscript Online	2015-08-21 13:58

ISSN	2307-8960 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Hematology
Manuscript Type	Review
Article Title	Targeting chronic lymphocytic leukemia cells in the tumor microenviroment: A review of the in vitro and clinical trials to date
Manuscript Source	Invited Manuscript
All Author List	Kyle Crassini, Stephen P Mulligan and O Giles Best
Funding Agency and Grant Number
Corresponding Author	Dr. O Giles Best, BSc (Hons), PhD, Northern Blood Research Centre and CLL Australian Research Consortium, Kolling Institute of Medical Research, Royal North Shore Hospital, St Leonards, Sydney NSW 2065, Australia. giles.best@sydney.edu.au
Key Words	Chronic lymphocytic leukemia; Therapy; Microenvironment; Leukemia; Novel
Core Tip	The treatment of chronic lymphocytic leukemia (CLL) is in a period of unprecedented revolution. A better understanding of the mechanisms that drive the survival and proliferation of CLL cells has led to the development of novel therapeutic strategies. This review article is a timely summary of the results of many of the recent key clinical and pre-clinical studies of novel therapeutic agents for CLL.
Publish Date	2015-08-21 13:58
Citation	Crassini K, Mulligan SP, Best OG. Targeting chronic lympho­cytic leukemia cells in the tumor microenviroment: A review of the in vitro and clinical trials to date. World J Clin Cases 2015; 3(8): 694-704
URL	http://www.wjgnet.com/2307-8960/full/v3/i8/694.htm
DOI	http://dx.doi.org/10.12998/wjcc.v3.i8.694

Full Article (PDF)	WJCC-3-694.pdf
Full Article (Word)	WJCC-3-694.doc
Manuscript File	15546-Review.docx
Answering Reviewers	15546-Answering reviewers.pdf
Audio Core Tip	15546-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	15546-Conflict-of-interest statement.pdf
Copyright License Agreement	15546-Copyright assignment.pdf
Peer-review Report	15546-Peer-review(s).pdf
Scientific Misconduct Check	15546-Scientific misconduct check.pdf
Scientific Editor Work List	15546-Scientific editor work list.pdf