Publication Name	World Journal of Psychiatry
Manuscript ID	15579
Country	France

Received	2014-11-29 13:12
Peer-Review Started	2014-11-29 15:00
To Make the First Decision	2014-12-26 13:16
Return for Revision	2015-01-03 13:44
Revised	2015-02-14 06:42
Second Decision	2015-04-22 17:11
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-05-06 15:36
Articles in Press	2015-05-06 15:44
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-06-09 09:19
Publish the Manuscript Online	2015-06-19 13:50

ISSN	2220-3206 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Psychiatry
Manuscript Type	Minireviews
Article Title	Inter-relationships between isotretinoin treatment and psychiatric disorders: Depression, bipolar disorder, anxiety, psychosis and suicide risks
Manuscript Source	Invited Manuscript
All Author List	Maude Ludot, Stephane Mouchabac and Florian Ferreri
Funding Agency and Grant Number
Corresponding Author	Florian Ferreri, MD, PhD, Psychiatry and Medical Psychology Department, Hospital Saint-Antoine, Univ Paris 06, Service de psychiatrie, 184 rue du faubourg Saint-Antoine, F-75012 Paris, France. florian.ferreri@upmc.fr
Key Words	Isotretinoin; Retinoic acid; Vitamin A; Suicide; Anxiety; Bipolar disorder; Psychosis; Schizophrenia
Core Tip	Isotretinoin is a treatment for severe acne. The prescription of this drug has been controversial ever since its initial marketing in 1982. This paper aims to specify the links between the drug and psychiatric disorders such as depression, suicide, anxiety, bipolar disorder and psychosis. Many studies demonstrated an increased risk of depression, attempted suicide and suicide following isotretinoin treatment. Several studies showed that patients with bipolar disorder had an increased risk for a clinical exacerbation of symptoms undergoing treatment with isotretinoin. A few studies also seem to suggest a possible link between isotretinoin and psychosis. From this review, we propose guidelines for isotretinoin prescription to healthcare professionals.
Publish Date	2015-06-19 13:50
Citation	Ludot M, Mouchabac S, Ferreri F. Inter-relationships between isotretinoin treatment and psychiatric disorders: Depression, bipolar disorder, anxiety, psychosis and suicide risks. World J Psychiatr 2015; 5(2): 222-227
URL	http://www.wjgnet.com/2220-3206/full/v5/i2/222.htm
DOI	http://dx.doi.org/10.5498/wjp.v5.i2.222

Full Article (PDF)	WJP-5-222.pdf
Full Article (Word)	WJP-5-222.doc
Manuscript File	15579-Review.docx
Answering Reviewers	15579-Answering reviewers.pdf
Audio Core Tip	15579-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	15579-Conflict-of-interest statement.pdf
Copyright License Agreement	15579-Copyright assignment.pdf
Peer-review Report	15579-Peer-review(s).pdf
Scientific Misconduct Check	15579-Scientific misconduct check.pdf
Scientific Editor Work List	15579-Scientific editor work list.pdf