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Publication Name World Journal of Translational Medicine
Manuscript ID 1558
Country/Territory United Kingdom
Received
2012-12-19 23:15
Peer-Review Started
2012-12-20 14:18
To Make the First Decision
2013-01-17 11:04
Return for Revision
2013-01-22 16:09
Revised
2013-01-24 01:30
Second Decision
2013-02-08 09:36
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2013-02-08 11:24
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2013-03-11 02:20
Publish the Manuscript Online
2013-03-22 14:59
ISSN 2220-6132 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Behavioral Sciences
Manuscript Type Review
Article Title Cognitive, behavioural and psychiatric phenotypes associated with steroid sulfatase deficiency
Manuscript Source Invited Manuscript
All Author List Simon Trent and William Davies
Funding Agency and Grant Number
Funding Agency Grant Number
Medical Research Council United Kingdom New Investigator Research Grant G0900636 (to Davies W)
Corresponding author William Davies, PhD, MRC Centre for Neuropsychiatric Genetics and Genomics, Henry Wellcome Building, Heath Park Campus, Cardiff CF14 4XN, United Kingdom. daviesw4@cardiff.ac.uk
Keywords Acetylcholine; Aggression; Attention; Attention deficit hyperactivity disorder; Dehydroepiandrosterone sulfate; Impulsivity; Hippocampus; Postpartum psychosis; Serotonin
Core Tip The enzyme steroid sulfatase (STS) cleaves sulfate groups from neuroactive steroid hormones thereby altering their activity. Here, we review cross-species evidence indicating that deficiency for this enzyme might influence behaviour and vulnerability to psychiatric illness; we then suggest potential mediating mechanisms. Understanding whether or not STS deficiency impacts upon neural function, and if so, how, has potential implications for diagnosis, counselling and treatment in cases of X-linked ichthyosis (the dermatological condition associated with STS deficiency). Moreover, this understanding may provide more general novel insights into the pathogenesis of common and disabling psychiatric disorders.
Publish Date 2013-03-22 14:59
Citation Trent S, Davies W. Cognitive, behavioural and psychiatric phenotypes associated with steroid sulfatase deficiency. World J Transl Med 2013; 2(1): 1-12
Url http://www.wjgnet.com/2220-6132/full/v2/i1/1.htm
DOI http://dx.doi.org/10.5528/wjtm.v2.i1.1
Full Article (PDF) WJTM-2-1.pdf
Manuscript File 1558-Review.doc
Answering Reviewers 1558-Answering reviewers.doc
Copyright License Agreement 1558-Copyright assignment.doc
Peer-review Report 1558-Peer review(s).docx
Scientific Editor Work List 1558-Scientific editor work list.doc