Publication Name	World Journal of Translational Medicine
Manuscript ID	1558
Country	United Kingdom

Received	2012-12-19 23:15
Peer-Review Started	2012-12-20 14:18
To Make the First Decision	2013-01-17 11:04
Return for Revision	2013-01-22 16:09
Revised	2013-01-24 01:30
Second Decision	2013-02-08 09:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-02-08 11:24
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-03-11 02:20
Publish the Manuscript Online	2013-03-22 14:59

ISSN	2220-6132 (online)
Open Access
Copyright
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Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Behavioral Sciences
Manuscript Type	Review
Article Title	Cognitive, behavioural and psychiatric phenotypes associated with steroid sulfatase deficiency
Manuscript Source	Invited Manuscript
All Author List	Simon Trent and William Davies
Funding Agency and Grant Number	Funding Agency Grant Number Medical Research Council United Kingdom New Investigator Research Grant G0900636 (to Davies W)
Corresponding Author	William Davies, PhD, MRC Centre for Neuropsychiatric Genetics and Genomics, Henry Wellcome Building, Heath Park Campus, Cardiff CF14 4XN, United Kingdom. daviesw4@cardiff.ac.uk
Key Words	Acetylcholine; Aggression; Attention; Attention deficit hyperactivity disorder; Dehydroepiandrosterone sulfate; Impulsivity; Hippocampus; Postpartum psychosis; Serotonin
Core Tip	The enzyme steroid sulfatase (STS) cleaves sulfate groups from neuroactive steroid hormones thereby altering their activity. Here, we review cross-species evidence indicating that deficiency for this enzyme might influence behaviour and vulnerability to psychiatric illness; we then suggest potential mediating mechanisms. Understanding whether or not STS deficiency impacts upon neural function, and if so, how, has potential implications for diagnosis, counselling and treatment in cases of X-linked ichthyosis (the dermatological condition associated with STS deficiency). Moreover, this understanding may provide more general novel insights into the pathogenesis of common and disabling psychiatric disorders.
Publish Date	2013-03-22 14:59
Citation	Trent S, Davies W. Cognitive, behavioural and psychiatric phenotypes associated with steroid sulfatase deficiency. World J Transl Med 2013; 2(1): 1-12
URL	http://www.wjgnet.com/2220-6132/full/v2/i1/1.htm
DOI	http://dx.doi.org/10.5528/wjtm.v2.i1.1

Full Article (PDF)	WJTM-2-1.pdf
Manuscript File	1558-Review.doc
Answering Reviewers	1558-Answering reviewers.doc
Copyright License Agreement	1558-Copyright assignment.doc
Peer-review Report	1558-Peer review(s).docx
Scientific Editor Work List	1558-Scientific editor work list.doc