Publication Name	World Journal of Hepatology
Manuscript ID	15644
Country	Egypt

Received	2014-12-02 09:55
Peer-Review Started	2014-12-02 12:19
To Make the First Decision	2015-01-08 14:05
Return for Revision	2015-01-12 19:47
Revised	2015-02-01 03:53
Second Decision	2015-08-12 18:46
Accepted by Journal Editor-in-Chief	2015-08-14 08:00
Accepted by Company Editor-in-Chief	2015-09-16 18:43
Articles in Press	2015-09-16 18:44
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-09-23 16:48
Publish the Manuscript Online	2015-10-19 16:02

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Role of biomarkers in the prediction and diagnosis of hepatocellular carcinoma
Manuscript Source	Invited Manuscript
All Author List	Mahmoud Khattab, Magdy Fouad and Elham Ahmed
Funding Agency and Grant Number
Corresponding Author	Mahmoud Khattab, MD, PhD, Professor of Medicine, Head of Liver Unit, Internal Medicine Department, Minia University, Main Road - Shalaby Land, Minia 61111, Egypt. mkhattabmed@hotmail.com
Key Words	Hepatocellular carcinoma; Epidemiology; Pathogenesis; Biomarkers; Diagnosis
Core Tip	Alpha-fetoprotein (AFP) has been widely used as a reference biomarker to validate the diagnosis of hepatocellular carcinoma (HCC). However, normal physiological-levels of AFP are observed in approximately one third of HCC cases. Furthermore, a number of HCC positive patients have AFP levels less than the threshold value of 400 ng/mL. These factors make an AFP-based diagnosis of HCC far from reliable. However, high diagnostic accuracy indices have been reported when AFP is combined with other biomarkers such as midkine, golgi protein 73, des-γ-carboxyprothrombin, glypican-3, and gamma-glutamyl transferase.
Publish Date	2015-10-19 16:02
Citation	Khattab M, Fouad M, Ahmed E. Role of biomarkers in the prediction and diagnosis of hepatocellular carcinoma. World J Hepatol 2015; 7(23): 2474-2481
URL	http://www.wjgnet.com/1948-5182/full/v7/i23/2474.htm
DOI	http://dx.doi.org/10.4254/wjh.v7.i23.2474

Full Article (PDF)	WJH-7-2474.pdf
Full Article (Word)	WJH-7-2474.doc
Manuscript File	15644-Review.doc
Answering Reviewers	15644-Answering reviewers.pdf
Audio Core Tip	15644-Audio core tip.MP3
Conflict-of-Interest Disclosure Form	15644-Conflict-of-interest statement.pdf
Copyright License Agreement	15644-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	15644-Language certificate.pdf
Peer-review Report	15644-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	15644-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	15644-Scientific misconduct check.pdf
Scientific Editor Work List	15644-Scientific editor work list.pdf