Publication Name	World Journal of Gastroenterology
Manuscript ID	1569
Country	Sweden

Received	2012-12-20 15:32
Peer-Review Started	2012-12-23 19:03
To Make the First Decision	2013-02-01 21:47
Return for Revision	2013-03-20 21:29
Revised	2013-04-04 03:06
Second Decision	2013-06-06 10:09
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-06-06 12:37
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-07-26 18:32
Publish the Manuscript Online	2013-08-13 11:13

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Genetics & Heredity
Manuscript Type	Autobiography
Article Title	Analysis of single nucleotide polymorphisms in the region of CLDN2-MORC4 in relation to inflammatory bowel disease
Manuscript Source	Invited Manuscript
All Author List	Jan Söderman, Elisabeth Norén, Malin Christiansson, Hanna Bragde, Raphaele Thiébaut, Jean-Pierre Hugot, Curt Tysk, Colm A O’Morain, Miquel Gassull, Yigael Finkel, Jean-Frédéric Colombel, Marc Lémann and Sven Almer
Funding Agency and Grant Number	Funding Agency Grant Number Futurum - the academy of healthcare, County council of Jönköping Swedish Society of Medicine Research Council of South-East Sweden (FORSS) County Council of Östergötland (ALF-Grants)
Corresponding Author	Elisabeth Norén, BSc, Division of Medical Diagnostics, Ryhov County Hospital, Sjukhusgatan, 55185 Jönköping, Sweden. elisabeth.noren@lj.se
Key Words	Crohn’s disease; Genetic predisposition; Inflammatory bowel disease; Single nucleotide polymorphism; Tight junctions
Core Tip	Tight junction proteins are key components in the regulation of paracellular permeability and therefore we considered claudin genes as candidate genes in the study. Association was identified between a single nucleotide polymorphism marker (rs12014762) in the CLDN2-MORC4 region and the occurrence of Crohn’s disease (CD) in a Swedish population. Additionally, a nonsynonymous coding single nucleotide polymorphism (rs6622126) in MORC4 was associated to CD. Our findings add further support for a genetically impaired intestinal epithelial barrier as one predisposing factor in the etiology of CD.
Publish Date	2013-08-13 11:13
Citation	S?derman J, Norén E, Christiansson M, Bragde H, Thiébaut R, Hugot JP, Tysk C, O’Morain CA, Gassull M, Finkel Y, Colombel JF, Lémann M, Almer S. Analysis of single nucleotide polymorphisms in the region of CLDN2-MORC4 in relation to inflammatory bowel disease. World J Gastroenterol 2013; 19(30): 4935-4943
URL	http://www.wjgnet.com/1007-9327/full/v19/i30/4935.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i30.4935

Full Article (PDF)	WJG-19-4935.pdf
Manuscript File	1569-Review.doc
Answering Reviewers	1569-Answering reviewers.pdf
Copyright License Agreement	1569-Copyright assignment.pdf
Peer-review Report	1569-Peer review(s).pdf
Scientific Editor Work List	1569-Scientific editor work list.doc