| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Systematic Reviews |
| Article Title |
Antioxidant drugs to prevent post-endoscopic retrograde cholangiopancreatography pancreatitis: What does evidence suggest?
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Clotilde Fuentes-Orozco, Carlos Dávalos-Cobián, Jesús García-Correa, Gabriela Ambriz-González, Michel Dassaejv Macías-Amezcua, Jesús García-Rentería, Jorge Rendón-Félix, Mariana Chávez-Tostado, Lizbeth Araceli Cuesta-Márquez, Andrea Socorro Alvarez-Villaseñor, Ana Olivia Cortés-Flores and Alejandro González-Ojeda |
| Funding Agency and Grant Number |
|
| Corresponding Author |
Alejandro González-Ojeda, MD, PhD, FACS, Research Unit in Clinical Epidemiology, Specialties Hospital of the Western Medical Center, Medical Unit of High Specialty, Mexican Institute of Social Security, Av. Belisario Domínguez 1000. Col. Independencia, Guadalajara, Jalisco 44340, México. avygail5@gmail.com |
| Key Words |
Antioxidant drugs; Endoscopic retrograde cholangiopancreatography; Pancreatitis; Prophylaxis |
| Core Tip |
Acute pancreatitis is considered one of the most serious complications after endoscopic retrograde cholangiopancreatography (ERCP). The mechanism of post-ERCP pancreatitis remains unclear but several studies show that free radicals play a role in its pathogenesis. Antioxidant drugs have been tested using different routes of administration and dosifications. The analysis of all randomized clinical trials published since 1999 did not revealed any significant reduction in the incidence and severity of post-endoscopic retrograde cholangiopancreatography pancreatitis (PEP) when compared with placebo. There is currently a lack of robust trials to support the use of antioxidants for the prevention of PEP. Well-designed placebo-controlled randomized controlled trials are warranted to determine any beneficial effect. |
| Publish Date |
2015-06-11 10:11 |
| Citation |
Fuentes-Orozco C, Dávalos-Cobián C, García-Correa J, Ambriz-González G, Macías-Amezcua MD, García-Rentería J, Rendón-Félix J, Chávez-Tostado M, Cuesta-Márquez LA, Alvarez-Villaseñor AS, Cortés-Flores AO, González-Ojeda A. Antioxidant drugs to prevent post-endoscopic retrograde cholangiopancreatography pancreatitis: What does evidence suggest? World J Gastroenterol 2015; 21(21): 6745-6753 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i21/6745.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i21.6745 |
