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Publication Name World Journal of Gastroenterology
Manuscript ID 15701
Country/Territory United States
Received
2014-12-04 10:57
Peer-Review Started
2014-12-05 16:43
To Make the First Decision
2015-03-10 17:59
Return for Revision
2015-03-12 10:31
Revised
2015-03-24 01:11
Second Decision
2015-05-04 08:14
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2015-05-07 15:33
Articles in Press
2015-05-07 15:34
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-05-23 18:35
Publish the Manuscript Online
2015-06-11 10:11
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Editorial
Article Title Cell therapy from bench to bedside: Hepatocytes from fibroblasts - the truth and myth of transdifferentiation
Manuscript Source Invited Manuscript
All Author List Madhusudana Girija Sanal
Funding Agency and Grant Number
Funding Agency Grant Number
IIP fellowship (2013-2014), Albert Einstein College of Medicine, New York, through the generosity of the Gruss Lipper Family Foundation
Corresponding Author Madhusudana Girija Sanal, MBBS, PhD, Department of Radiation Oncology, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Room 323, Ullmann Building, 1300 Morris Park Avenue, Bronx, NY 10461, United States. sanalmg@gmail.com
Key Words Trans differentiation; i-Heps; Fibroblasts; Induced pluripotent stem cells; Embryonic stem cells; Hepatocyte like cells; Telomere/telomerase; Hepatocyte transplantation; differentiation; Inherited/genetic liver disease; Cell therapy; Gene therapy
Core Tip Hepatocyte transplantation is an alternative for liver transplantation in chronic liver disease patients for a long term cure. There is a scarcity of donor liver and hepatocytes. Induced pluripotent stem cells (iPSC) derived hepatocytes and hepatocytes generated by transdifferentiation are two possibilities. iPSC derived hepatocytes often fail to engraft upon transplantation. We need to define methods to evaluate and compare efficiency of differentiation, standards and clear quality definition for hepatocyte like cells. More comprehensive analysis of the RNAs and proteome is required. Methods to compare and analyze the expression profiles, standards and references to be compared with need to be defined. There is a need for a well-coordinated global initiative comparable to the scale of the Human Genome Project to achieve this goal in the near future.
Publish Date 2015-06-11 10:11
Citation Sanal MG. Cell therapy from bench to bedside: Hepatocytes from fibroblasts - the truth and myth of transdifferentiation. World J Gastroenterol 2015; 21(21): 6427-6433
URL http://www.wjgnet.com/1007-9327/full/v21/i21/6427.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i21.6427
Full Article (PDF) WJG-21-6427.pdf
Full Article (Word) WJG-21-6427.doc
Manuscript File 15701-Review.docx
Answering Reviewers 15701-Answering reviewers.pdf
Audio Core Tip 15701-Audio core tip.wma
Conflict-of-Interest Disclosure Form 15701-Conflict-of-interest statement.pdf
Copyright License Agreement 15701-Copyright assignment.pdf
Peer-review Report 15701-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 15701-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 15701-Scientific misconduct check.pdf
Scientific Editor Work List 15701-Scientific editor work list.pdf