Publication Name	World Journal of Gastroenterology
Manuscript ID	15701
Country	United States

Received	2014-12-04 10:57
Peer-Review Started	2014-12-05 16:43
To Make the First Decision	2015-03-10 17:59
Return for Revision	2015-03-12 10:31
Revised	2015-03-24 01:11
Second Decision	2015-05-04 08:14
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-05-07 15:33
Articles in Press	2015-05-07 15:34
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-05-23 18:35
Publish the Manuscript Online	2015-06-11 10:11

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Cell therapy from bench to bedside: Hepatocytes from fibroblasts - the truth and myth of transdifferentiation
Manuscript Source	Invited Manuscript
All Author List	Madhusudana Girija Sanal
Funding Agency and Grant Number	Funding Agency Grant Number IIP fellowship (2013-2014), Albert Einstein College of Medicine, New York, through the generosity of the Gruss Lipper Family Foundation
Corresponding Author	Madhusudana Girija Sanal, MBBS, PhD, Department of Radiation Oncology, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Room 323, Ullmann Building, 1300 Morris Park Avenue, Bronx, NY 10461, United States. sanalmg@gmail.com
Key Words	Trans differentiation; i-Heps; Fibroblasts; Induced pluripotent stem cells; Embryonic stem cells; Hepatocyte like cells; Telomere/telomerase; Hepatocyte transplantation; differentiation; Inherited/genetic liver disease; Cell therapy; Gene therapy
Core Tip	Hepatocyte transplantation is an alternative for liver transplantation in chronic liver disease patients for a long term cure. There is a scarcity of donor liver and hepatocytes. Induced pluripotent stem cells (iPSC) derived hepatocytes and hepatocytes generated by transdifferentiation are two possibilities. iPSC derived hepatocytes often fail to engraft upon transplantation. We need to define methods to evaluate and compare efficiency of differentiation, standards and clear quality definition for hepatocyte like cells. More comprehensive analysis of the RNAs and proteome is required. Methods to compare and analyze the expression profiles, standards and references to be compared with need to be defined. There is a need for a well-coordinated global initiative comparable to the scale of the Human Genome Project to achieve this goal in the near future.
Publish Date	2015-06-11 10:11
Citation	Sanal MG. Cell therapy from bench to bedside: Hepatocytes from fibroblasts - the truth and myth of transdifferentiation. World J Gastroenterol 2015; 21(21): 6427-6433
URL	http://www.wjgnet.com/1007-9327/full/v21/i21/6427.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i21.6427

Full Article (PDF)	WJG-21-6427.pdf
Full Article (Word)	WJG-21-6427.doc
Manuscript File	15701-Review.docx
Answering Reviewers	15701-Answering reviewers.pdf
Audio Core Tip	15701-Audio core tip.wma
Conflict-of-Interest Disclosure Form	15701-Conflict-of-interest statement.pdf
Copyright License Agreement	15701-Copyright assignment.pdf
Peer-review Report	15701-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	15701-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	15701-Scientific misconduct check.pdf
Scientific Editor Work List	15701-Scientific editor work list.pdf