Publication Name	World Journal of Respirology
Manuscript ID	15703
Country	Japan

Received	2014-12-05 09:27
Peer-Review Started	2014-12-07 19:56
To Make the First Decision	2014-12-26 13:11
Return for Revision	2015-01-03 15:55
Revised	2015-01-06 10:32
Second Decision	2015-01-14 08:31
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-01-20 16:52
Articles in Press	2015-01-20 16:52
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-03-10 15:28
Publish the Manuscript Online	2015-03-23 14:01

ISSN	2218-6255 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Medicine, General & Internal
Manuscript Type	Editorial
Article Title	Polymyxin B-immobilized fiber columns: A column to breathe new life into the treatment of interstitial lung disease?
Manuscript Source	Invited Manuscript
All Author List	Katsuaki Asakawa and Toshinori Takada
Funding Agency and Grant Number
Corresponding Author	Toshinori Takada, MD, PhD, Professor, Director of the Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital, Niigata 951-8520, Japan. ttakada@med.niigata-u.ac.jp
Key Words	Acute exacerbation; Idiopathic pulmonary fibrosis; Polymyxin B; Hemoperfusion; Interstitial lung disease
Core Tip	Application of direct hemoperfusion with polymyxin B-immobilized fiber columns (PMX-DHP) to the treatment of acute exacerbations of idiopathic pulmonary fibrosis may improve oxygenation and survival of the patients with the disease. PMX-DHP performed on the first day of steroid pulse therapy may improve the prognosis of patients with rapidly progressive interstitial lung diseases in a case-control setting. PMX treatment decreases not only various circulating molecules but also inflammatory cells, in particular activated monocytes, producing such mediators. In order to test the effects of PMX-DHP on the disease, a cohort or case-control analytic study needs to be conducted, preferably from more than one center or research group.
Publish Date	2015-03-23 14:01
Citation	Asakawa K, Takada T. Polymyxin B-immobilized fiber columns: A column to breathe new life into the treatment of interstitial lung disease? World J Respirol 2015; 5(1): 1-3
URL	http://www.wjgnet.com/2218-6255/full/v5/i1/1.htm
DOI	http://dx.doi.org/10.5320/wjr.v5.i1.1

Full Article (PDF)	WJR-5-1.pdf
Full Article (Word)	WJR-5-1.doc
Manuscript File	15703-Review.doc
Answering Reviewers	15703 Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	15703-Conflict-of-interest statement.pdf
Copyright License Agreement	15703 Copyright assignment.pdf
Peer-review Report	15703-Peer review(s).pdf
Scientific Misconduct Check	15703-CrossCheck.jpg
Scientific Editor Work List	15703-Scientific editor work list.pdf