Publication Name	World Journal of Gastroenterology
Manuscript ID	15712
Country	China

Received	2014-12-05 09:11
Peer-Review Started	2014-12-05 18:13
To Make the First Decision	2015-01-08 16:58
Return for Revision	2015-01-12 18:57
Revised	2015-01-23 14:25
Second Decision	2015-03-11 15:32
Accepted by Journal Editor-in-Chief	2015-03-12 16:14
Accepted by Executive Editor-in-Chief	2015-03-19 17:27
Articles in Press	2015-03-19 17:47
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-04-23 20:24
Typeset the Manuscript	2015-06-18 14:11
Publish the Manuscript Online	2015-07-08 12:01

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Overexpression of HMGB1 A-box reduced lipopolysaccharide-induced intestinal inflammation via HMGB1/TLR4 signaling in vitro
Manuscript Source	Unsolicited Manuscript
All Author List	Fu-Cai Wang, Jing-Xuan Pei, Jun Zhu, Nan-Jin Zhou, Dong-Sheng Liu, Hui-Fang Xiong, Xiao-Qun Liu, Dong-Jia Lin and Yong Xie
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81160056 Youth Science Foundation of Jiangxi Provincial, China 20132BAB215017
Corresponding Author	Yong Xie, PhD, Professor, Chief Physician, Department of Gastroenterology, the First Affiliated Hospital of Nanchang University, Gastroenterology Institute of Jiangxi Province, Key Laboratory of Digestive Diseases of Jiangxi Province, No. 17 Yongwaizheng Street, Nanchang 330006, Jiangxi Province, China. xieyong_med@163.com
Key Words	High mobility group box 1; Toll-like receptor 4; HMGB1 A-box; Ethyl pyruvate; Inflammatory bowel disease
Core Tip	We have provided the first report that high mobility group box (HMGB)1 A-box, not only ethyl py?ruvate, can specifically inhibit HMGB1/toll-like receptor 4 signaling pathways and reduce lipopolysaccharide-induced intestinal inflammation. Our findings indicate the potential of the HMGB1 A-box as a novel approach in the treatment of inflammatory bowel disease.
Publish Date	2015-07-08 12:01
Citation	Wang FC, Pei JX, Zhu J, Zhou NJ, Liu DS, Xiong HF, Liu XQ, Lin DJ, Xie Y. Overexpression of HMGB1 A-box reduced lipopolysaccharide-induced intestinal inflammation via HMGB1/TLR4 signaling in vitro. World J Gastroenterol 2015; 21(25): 7764-7776
URL	http://www.wjgnet.com/1007-9327/full/v21/i25/7764.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i25.7764

Full Article (PDF)	WJG-21-7764.pdf
Full Article (Word)	WJG-21-7764.doc
Manuscript File	15712-Review.doc
Answering Reviewers	15712-Answering reviewers.pdf
Audio Core Tip	15712-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	Conflict-of-Interest_Statement_20141204225927.doc
Copyright License Agreement	15712-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	15712-Language certificate.pdf
Peer-review Report	15712-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	15712-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	15712-Scientific misconduct check.pdf
Scientific Editor Work List	15712-Scientific editor work list.pdf