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Articles Published Processes
5/21/2015 2:15:00 PM | Browse: 1196 | Download: 1901
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Received |
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2014-12-06 15:18 |
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Peer-Review Started |
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2014-12-06 22:34 |
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To Make the First Decision |
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2015-01-20 13:41 |
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Return for Revision |
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2015-01-20 17:51 |
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Revised |
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2015-03-18 00:00 |
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Second Decision |
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2015-04-01 15:25 |
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Accepted by Journal Editor-in-Chief |
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2015-04-01 18:30 |
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Accepted by Executive Editor-in-Chief |
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2015-04-14 16:07 |
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Articles in Press |
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2015-04-14 16:08 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-04-22 16:05 |
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Publish the Manuscript Online |
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2015-05-21 14:15 |
| ISSN |
2220-315x (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Review |
| Article Title |
Endothelium-derived essential signals involved in pancreas organogenesis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Dodanim Talavera-Adame and Donald C Dafoe |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Eris M. Field Endowment for Diabetes Research assigned to Donald C Dafoe |
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| Corresponding Author |
Donald C Dafoe, MD, Professor of Surgery, Clinical Professor of Surgery, UCLA, Eris M. Field Chair in Diabetes Research, Vice-Chair of Education, Director, Comprehensive Transplant Center, Department of Surgery, Cedars-Sinai Medical Center, 8635 W. Third Street, Suite 590W, Los Angeles, CA 90048, United States. donald.dafoe@cshs.org |
| Key Words |
Endothelium; Endothelium-derived signals; Differentiation; Pancreas development; Organogenesis |
| Core Tip |
Many studies have demonstrated that endothelial cells (ECs) have an important role in organogenesis. For instance, during embryogenesis, aortic ECs provide specific factors that maintain the expression of key genes for pancreas development. Other unknown factors are also important for pancreatic endocrine specification and formation of insulin-producing beta cells. In addition, by the end of the gestation and close to birth, pancreatic islets contain immature beta cells with the capacity to express factors that recruit ECs from the surrounding microenvironment and form a functional unit that will lasts for the whole life of the individual. In the present review, we will analyze the current endothelial-derived factors called angiocrine factors that are essential in organogenesis and we will focus the role of these factors in pancreas development and pancreatic beta cells. |
| Publish Date |
2015-05-21 14:15 |
| Citation |
Talavera-Adame D, Dafoe DC. Endothelium-derived essential signals involved in pancreas organogenesis. World J Exp Med 2015; 5(2): 40-49 |
| URL |
http://www.wjgnet.com/2220-315X/full/v5/i2/40.htm |
| DOI |
http://dx.doi.org/10.5493/wjem.v5.i2.40 |
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