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5/21/2015 2:15:00 PM | Browse: 1037 | Download: 1549
Publication Name World Journal of Experimental Medicine
Manuscript ID 15735
Country/Territory United States
Received
2014-12-06 15:18
Peer-Review Started
2014-12-06 22:34
To Make the First Decision
2015-01-20 13:41
Return for Revision
2015-01-20 17:51
Revised
2015-03-18 00:00
Second Decision
2015-04-01 15:25
Accepted by Journal Editor-in-Chief
2015-04-01 18:30
Accepted by Company Editor-in-Chief
2015-04-14 16:07
Articles in Press
2015-04-14 16:08
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-04-22 16:05
Publish the Manuscript Online
2015-05-21 14:15
ISSN 2220-315x (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Cell Biology
Manuscript Type Review
Article Title Endothelium-derived essential signals involved in pancreas organogenesis
Manuscript Source Invited Manuscript
All Author List Dodanim Talavera-Adame and Donald C Dafoe
Funding Agency and Grant Number
Funding Agency Grant Number
Eris M. Field Endowment for Diabetes Research assigned to Donald C Dafoe
Corresponding Author Donald C Dafoe, MD, Professor of Surgery, Clinical Professor of Surgery, UCLA, Eris M. Field Chair in Diabetes Research, Vice-Chair of Education, Director, Comprehensive Transplant Center, Department of Surgery, Cedars-Sinai Medical Center, 8635 W. Third Street, Suite 590W, Los Angeles, CA 90048, United States. donald.dafoe@cshs.org
Key Words Endothelium; Endothelium-derived signals; Differentiation; Pancreas development; Organogenesis
Core Tip Many studies have demonstrated that endothelial cells (ECs) have an important role in organogenesis. For instance, during embryogenesis, aortic ECs provide specific factors that maintain the expression of key genes for pancreas development. Other unknown factors are also important for pancreatic endocrine specification and formation of insulin-producing beta cells. In addition, by the end of the gestation and close to birth, pancreatic islets contain immature beta cells with the capacity to express factors that recruit ECs from the surrounding microenvironment and form a functional unit that will lasts for the whole life of the individual. In the present review, we will analyze the current endothelial-derived factors called angiocrine factors that are essential in organogenesis and we will focus the role of these factors in pancreas development and pancreatic beta cells.
Publish Date 2015-05-21 14:15
Citation Talavera-Adame D, Dafoe DC. Endothelium-derived essential signals involved in pancreas organogenesis. World J Exp Med 2015; 5(2): 40-49
URL http://www.wjgnet.com/2220-315X/full/v5/i2/40.htm
DOI http://dx.doi.org/10.5493/wjem.v5.i2.40
Full Article (PDF) WJEM-5-40.pdf
Full Article (Word) WJEM-5-40.doc
Manuscript File 15735-Review.docx
Answering Reviewers 15735-Answering reviewers.pdf
Audio Core Tip 15735-Audio core tip.mov
Conflict-of-Interest Disclosure Form 15735-Conflict-of-interest statement.pdf
Copyright License Agreement 15735-Copyright assignment.pdf
Peer-review Report 15735-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 15735-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 15735-Scientific misconduct check.pdf
Scientific Editor Work List 15735-Scientific editor work list.pdf