Publication Name	World Journal of Gastroenterology
Manuscript ID	15746
Country	Brazil

Received	2014-12-08 10:09
Peer-Review Started	2014-12-08 12:19
To Make the First Decision	2015-01-22 16:48
Return for Revision	2015-01-27 16:18
Revised	2015-02-14 21:20
Second Decision	2015-04-07 07:58
Accepted by Journal Editor-in-Chief	2015-04-07 17:10
Accepted by Company Editor-in-Chief	2015-04-09 17:10
Articles in Press	2015-04-09 17:18
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-05-27 14:26
Publish the Manuscript Online	2015-06-18 17:32

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Surgery
Manuscript Type	Observational Study
Article Title	Metabolic surgery and intestinal gene expression: Digestive tract and diabetes evolution considerations
Manuscript Source	Unsolicited Manuscript
All Author List	Marcos Ricardo da Silva Rodrigues, Marco Aurelio Santo, Giovani Marino Favero, Elaine Cristina Vieira, Roberto Ferreira Artoni, Viviane Nogaroto, Egberto Gaspar de Moura, Patricia Lisboa and Fabio Quirillo Milleo
Funding Agency and Grant Number	Funding Agency Grant Number Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro Instituto de Pesquisas Aplicadas à Medicina Coordenação de Aperfeiçoamento de Pessoal de Nível Superior Fundação Araucária Conselho Nacional de Desenvolvimento Científico e Tecnológico Secretaria de Estado da Ciência, Tecnologia e Ensino Superior/Unidade Gestora do Fundo do Paraná
Corresponding Author	Fabio Quirillo Milleo, MD, PhD, Labora¬tório Multidisciplinar da Universidade Estadual de Ponta Grossa-Campus Uvaranas, Avenida General Carlos Cavalcanti, 474, CEP 84030-900 Ponta Grossa, Paraná, Brazil. fqmilleo58@gmail.com
Key Words	Diabetes mellitus; Hyperglycemia; Intestine; Gene expression; Hyperplasia; Bariatric surgery
Core Tip	This study shows an improvement in expression of antiproliferative genes of intestinal mucosa after type 2 diabetes mellitus amelioration promoted by metabolic surgery procedure. We make a link between this outcome and morphological changes in intestinal mucosa on diabetes, that occurs mainly by insufficient negative control of mucosal growth in hyperglycemia. Metabolic and bariatric surgery promotes dramatic amelioration of glucose metabolism in diabetic patients by not completely understood means. This paper highlights for the first time, the intestinal absorptive capacity as the main focus for research of diabetes amelioration after metabolic surgery procedures.
Publish Date	2015-06-18 17:32
Citation	Rodrigues MRS, Santo MA, Favero GM, Vieira EC, Artoni RF, Nogaroto V, Moura EG, Lisboa P, Milleo FQ. Metabolic surgery and intestinal gene expression: Digestive tract and diabetes evolution considerations. World J Gastroenterol 2015; 21(22): 6990-6998
URL	http://www.wjgnet.com/1007-9327/full/v21/i22/6990.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i22.6990

Full Article (PDF)	WJG-21-6990.pdf
Full Article (Word)	WJG-21-6990.doc
Manuscript File	15746-Review.doc
Answering Reviewers	15746-Answering reviewers.pdf
Audio Core Tip	15746-Audio core tip.mp3
Biostatistics Review Certificate	15746-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	15746-Conflict-of-interest statement.pdf
Copyright License Agreement	15746-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	15746-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	15746-Language certificate.pdf
Peer-review Report	15746-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	15746-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	15746-Scientific misconduct check.pdf
Scientific Editor Work List	15746-Scientific editor work list.pdf