Publication Name	World Journal of Immunology
Manuscript ID	15758
Country	Israel

Received	2014-12-08 09:39
Peer-Review Started	2014-12-09 09:38
To Make the First Decision	2014-12-26 13:10
Return for Revision	2015-01-03 16:56
Revised	2015-01-14 16:31
Second Decision	2015-02-26 17:38
Accepted by Journal Editor-in-Chief	2015-02-27 01:25
Accepted by Executive Editor-in-Chief	2015-06-08 15:58
Articles in Press	2015-06-08 16:27
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-07-07 14:37
Publish the Manuscript Online	2015-08-04 10:49

ISSN	2219-2824 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Oncology
Manuscript Type	Minireviews
Article Title	GRP78 expression beyond cellular stress: A biomarker for tumor manipulation
Manuscript Source	Invited Manuscript
All Author List	Britta Hardy and Annat Raiter
Funding Agency and Grant Number
Corresponding Author	Britta Hardy, PhD, Professor, Director, Felsenstein Medical Research Center, Tel-Aviv University School of Medicine, Rabin Medical Center, Beilinson Campus, Petach Tikva 49100, Israel. brittah23@gmail.com
Key Words	Cell surface GRP78; Apoptosis; Endoplasmic reticulum stress; Tumor cells; Cancer; Cardiovascular ischemia; Hypoxia
Core Tip	In the prolonged chronic stress transportation of the GRP78 from the endoplasmic reticulum to the cell membrane is a major event where in addition to the presentation of the GRP78 as a receptor to various ligands, it also marks the cells that will proceed to apoptotic pathways. In the normal cell that under stress acquires cell surface GRP78 and in the tumor cell that already presents cell surface GRP78, cell surface GRP78 is an apoptotic flag. This review analyzes the input of cell surface GRP78 on apoptosis in normal and tumor cells.
Publish Date	2015-08-04 10:49
Citation	Hardy B , Raiter A. GRP78 expression beyond cellular stress: A biomarker for tumor manipulation. World J Immunol 2015; 5(2): 78-85
URL	http://www.wjgnet.com/2219-2824/full/v5/i2/78.htm
DOI	http://dx.doi.org/10.5411/wji.v5.i2.78

Full Article (PDF)	WJI-5-78.pdf
Full Article (Word)	WJI-5-78.doc
Manuscript File	15758-Review.docx
Answering Reviewers	15758-Answering reviewers.pdf
Audio Core Tip	15758-Audio core tip.aiff
Conflict-of-Interest Disclosure Form	15758-Conflict-of-interest statement.pdf
Copyright License Agreement	15758-Copyright assignment.pdf
Peer-review Report	15758-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	15758-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	15758-Scientific misconduct check.pdf
Scientific Editor Work List	15758-Scientific editor work list.pdf