Publication Name	World Journal of Gastroenterology
Manuscript ID	15765
Country	United States

Received	2014-12-08 08:55
Peer-Review Started	2014-12-09 08:14
To Make the First Decision	2015-01-22 16:38
Return for Revision	2015-02-02 10:11
Revised	2015-02-13 00:19
Second Decision	2015-03-23 08:05
Accepted by Journal Editor-in-Chief	2015-03-23 17:45
Accepted by Executive Editor-in-Chief	2015-03-27 17:51
Articles in Press	2015-03-27 18:17
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-04-14 21:39
Publish the Manuscript Online	2015-04-27 16:22

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Challenges in animal modelling of mesenchymal stromal cell therapy for inflammatory bowel disease
Manuscript Source	Invited Manuscript
All Author List	Raghavan Chinnadurai, Spencer Ng, Vijayakumar Velu and Jacques Galipeau
Funding Agency and Grant Number
Corresponding Author	Jacques Galipeau, Professor, Department of Hematology and Oncology, Winship Cancer Institute, Emory University, 1365-C Clifton Road NE, Atlanta, GA 30322, United States. jgalipe@emory.edu
Key Words	Mesenchymal stromal cells; Inflammatory bowel disease; colitis; Animal model; Crohn’s disaese
Core Tip	Several clinical trials have investigated the use of mesenchymal stromal cells (MSCs) for the treatment of inflammatory bowel disease. Although MSC therapy has proven to be safe, efficacy remains to be determined. Animal model studies are necessary to evaluate the efficacy and mechanism of action of MSCs, which will improve ongoing clinical trials. However, clinical translation is largely hampered by (1) variability of colitis animal models available; and (2) differences in the biology of murine and human MSC counterparts. Here we discuss the challenges and approaches of translating animal studies to clinical trials.
Publish Date	2015-04-27 16:22
Citation	Chinnadurai R, Ng S, Velu V, Galipeau J. Challenges in animal modelling of mesenchymal stromal cell therapy for inflammatory bowel disease. World J Gastroenterol 2015; 21(16): 4779-4787
URL	http://www.wjgnet.com/1007-9327/full/v21/i16/4779.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i16.4779

Full Article (PDF)	WJG-21-4779.pdf
Full Article (Word)	WJG-21-4779.doc
Manuscript File	15765-Review.docx
Answering Reviewers	15765-Answering reviewers.pdf
Audio Core Tip	15765-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	15765-Conflict-of-interest statement.pdf
Copyright License Agreement	15765-Copyright assignment.PDF
Peer-review Report	15765-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	15765-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	15765-Scientific misconduct check.pdf
Scientific Editor Work List	15765-Scientific editor work list.pdf