Publication Name	World Journal of Diabetes
Manuscript ID	1578
Country	Italy

Received	2012-12-20 21:52
Peer-Review Started	2012-12-22 17:13
First Decision by Editorial Office Director
Return for Revision	2013-01-06 10:09
Revised	2013-02-22 20:43
Publication Fee Transferred
Second Decision by Editor	2013-03-22 12:02
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2013-03-23 09:24
Articles in Press
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-04-11 22:09
Publish the Manuscript Online	2013-04-15 20:21

ISSN	1948-9358 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Endocrinology & Metabolism
Manuscript Type	Autobiography
Article Title	Negative association between trunk fat, insulin resistance and skeleton in obese women
Manuscript Source	Invited Manuscript
All Author List	Emanuela A Greco, Davide Francomano, Rachele Fornari, Chiara Marocco, Carla Lubrano, Vincenza Papa, Francesca Wannenes, Luigi Di Luigi, Lorenzo M Donini, Andrea Lenzi, Antonio Aversa and Silvia Migliaccio
Funding Agency and Grant Number
Corresponding Author	Silvia Migliaccio, MD, PhD, Endocrinology Unit, Department of Movement, Human and Health Sciences, University Foro Italico, Largo Lauro De Bosis 15, 00195 Rome, Italy. silvia.migliaccio@uniroma4.it
Key Words	Obesity; Skeleton; Vitamin D; Osteocalcin; Insulin resistance; Trunk fat; Inflammation
Core Tip	Recent studies have shown that high fat mass content might be a risk factor for osteoporosis and fragility fractures. We evaluated obese women for vitamin D, osteocalcin, inflammatory markers, metabolic and hormones profile, bone mineral density (BMD) and body composition by dual-energy X-ray absorptiometry. Our results show that in obese women trunk fat negatively correlates with BMD independently from vitamin D levels, likely as consequence of reduced insulin-like growth factor-1 and increased inflammatory markers. These data indicate that obesity cannot be considered a protective factor for osteoporosis and suggest that obese postmenopausal women should be investigated for possible alterations of skeletal metabolism.
Publish Date	2013-04-15 20:21
Citation	Greco EA, Francomano D, Fornari R, Marocco C, Lubrano C, Papa V, Wannenes F, Di Luigi L, Donini LM, Lenzi A, Aversa A, Migliaccio S. Negative association between trunk fat, insulin resistance and skeleton in obese women. World J Diabetes 2013; 4(2): 31-39
URL	http://www.wjgnet.com/1948-9358/full/v4/i2/31.htm
DOI	http://dx.doi.org/10.4239/wjd.v4.i2.31

Full Article (PDF)	WJD-4-31.pdf
Manuscript File	1578-Review.docx
Answering Reviewers	1578-Answering reviewers.doc
Copyright License Agreement	1578-Copyright assignment.pdf
Peer-review Report	1578-Peer reviewer(s).pdf
Scientific Editor Work List	1578-Scientific editor work list.doc