Publication Name	World Journal of Gastroenterology
Manuscript ID	15844
Country	Japan

Received	2014-12-16 11:14
Peer-Review Started	2014-12-16 13:02
To Make the First Decision	2015-01-22 16:37
Return for Revision	2015-02-02 10:15
Revised	2015-02-13 23:55
Second Decision	2015-03-16 16:41
Accepted by Journal Editor-in-Chief	2015-03-17 03:54
Accepted by Company Editor-in-Chief	2015-03-19 17:01
Articles in Press	2015-03-19 17:44
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-04-10 08:33
Typeset the Manuscript	2015-06-30 17:41
Publish the Manuscript Online	2015-07-14 12:17

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Randomized Controlled Trial
Article Title	Safety and efficacy of carbon dioxide insufflation during gastric endoscopic submucosal dissection
Manuscript Source	Unsolicited Manuscript
All Author List	Jun Takada, Hiroshi Araki, Fumito Onogi, Takayuki Nakanishi, Masaya Kubota, Takashi Ibuka, Masahito Shimizu and Hisataka Moriwaki
Funding Agency and Grant Number
Corresponding Author	Hiroshi Araki, MD, PhD, Assistant Professor, Department of Gastroenterology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 5011194, Japan. araara@gifu-u.ac.jp
Key Words	Carbon dioxide; Gastric endoscopic submucosal dissection; Insufflation; Mallory-Weiss tear; Randomized controlled trial
Core Tip	The safety and efficacy of carbon dioxide (CO2) and air insufflation during gastric endoscopic submucosal dissection (ESD) were compared in a randomized controlled trial. The transcutaneous CO2 tension and the partial pressure of CO2 in the arterial blood were measured to directly evaluate CO2 retention or acidemia. The findings strongly suggest that CO2 insufflation is as safe as air insufflation with regard to blood gas levels. The present study is the first randomized controlled trial to demonstrate the benefit of CO2 insufflation in reducing the risk of Mallory-Weiss tears during ESD.
Publish Date	2015-07-14 12:17
Citation	Takada J, Araki H, Onogi F, Nakanishi T, Kubota M, Ibuka T, Shimizu M, Moriwaki H. Safety and efficacy of carbon dioxide insufflation during gastric endoscopic submucosal dissection. World J Gastroenterol 2015; 21(26): 8195-8202
URL	http://www.wjgnet.com/1007-9327/full/v21/i26/8195.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i26.8195

Full Article (PDF)	WJG-21-8195.pdf
Full Article (Word)	WJG-21-8195.doc
Manuscript File	15844-Review.docx
Answering Reviewers	15844-Answering reviewers.pdf
Audio Core Tip	15844-Audio core tip.mp3
Biostatistics Review Certificate	15844-Biostatistics statement.pdf
Clinical Trial Registration Statement	15844-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form	15844-Conflict-of-interest statement.pdf
Copyright License Agreement	15844-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	15844-Clinical trial registration statement.pdf
Institutional Review Board Approval Form or Document	15844-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	15844-Language certificate.pdf
Peer-review Report	15844-Peer-review(s).pdf
Scientific Misconduct Check	15844-Scientific misconduct check.pdf
Scientific Editor Work List	15844-Scientific editor work list.pdf