Publication Name	World Journal of Stem Cells
Manuscript ID	15863
Country	Austria

Received	2014-12-13 19:01
Peer-Review Started	2014-12-22 09:15
To Make the First Decision	2015-01-20 13:30
Return for Revision	2015-01-30 17:12
Revised	2015-03-01 01:35
Second Decision	2015-04-10 18:09
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-04-20 14:34
Articles in Press	2015-04-20 14:34
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-06-12 11:45
Publish the Manuscript Online	2015-06-30 08:56

ISSN	1948-0210 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Cardiac & Cardiovascular Systems
Manuscript Type	Review
Article Title	Contemporary perspective on endogenous myocardial regeneration
Manuscript Source	Invited Manuscript
All Author List	Dejan Milasinovic and Werner Mohl
Funding Agency and Grant Number
Corresponding Author	Werner Mohl, MD, PhD, Professor, Department of Cardiac Surgery, Medical University of Vienna, AKH Wien, Waehringerguertel 18-20, 1090 Vienna, Austria. werner.mohl@meduniwien.ac.at
Key Words	Cardiac regeneration; Cardiac development; Embryonic recall; Pressure-controlled intermittent coronary sinus occlusion; Heart failure; Myocardial infarction
Core Tip	Unlike in primitive vertebrates, any regenerative effort in adult mammalian hearts after an acute event remains unsatisfactory. Most efforts to repopulate failing hearts with functioning and integrated cardiomyocytes have not achieved clinical importance. In this overview, after describing several options for endogenous myo?cardial repair, we support the notion of a paradigm change towards inducible developmental processes in regeneration research. Major efforts have been made to convert tissues upstream in the Waddington scheme. Recently, stress transformed acquired pluripotency raised enormous expectations, but results and proof of concept were seriously questioned. We want to introduce pressure-controlled intermittent coronary sinus occlusion as a potential resource to decipher the unsolved equation of re-inducing the developmental processes in the human heart.
Publish Date	2015-06-30 08:56
Citation	Milasinovic D, Mohl W. Contemporary perspective on endogenous myocardial regeneration. World J Stem Cells 2015; 7(5): 793-805
URL	http://www.wjgnet.com/1948-0210/full/v7/i5/793.htm
DOI	http://dx.doi.org/10.4252/wjsc.v7.i5.793

Full Article (PDF)	WJSC-7-793.pdf
Full Article (Word)	WJSC-7-793.doc
Manuscript File	15863-Review.docx
Answering Reviewers	15863-Answering reviewers.pdf
Audio Core Tip	15863-Audio core tip.wma
Conflict-of-Interest Disclosure Form	15863-Conflict-of-interest statement.pdf
Copyright License Agreement	15863-Copyright assignment.pdf
Peer-review Report	15863-Peer-reivew(s).pdf
Scientific Misconduct Check	15863-Scientific misconduct check.pdf
Scientific Editor Work List	15863-Scientific editor work list.pdf