Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	15877
Country	United States

Received	2014-12-16 10:07
Peer-Review Started	2014-12-16 19:53
To Make the First Decision	2015-03-06 10:34
Return for Revision	2015-03-11 10:38
Revised	2015-03-18 04:01
Second Decision	2015-04-10 18:17
Accepted by Journal Editor-in-Chief	2015-04-10 18:33
Accepted by Executive Editor-in-Chief	2015-04-20 14:39
Articles in Press	2015-04-20 14:39
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-05-15 14:28
Publish the Manuscript Online	2015-05-18 09:19

ISSN	1948-5204 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Oncology
Manuscript Type	Editorial
Article Title	Epigenetic reduction of DNA repair in progression to gastrointestinal cancer
Manuscript Source	Invited Manuscript
All Author List	Carol Bernstein and Harris Bernstein
Funding Agency and Grant Number
Corresponding Author	Carol Bernstein, Research Associate Professor, Department of Cellular and Molecular Medicine, College of Medicine, University of Arizona, Tucson, AZ 85724, United States. bernstein324@yahoo.com
Key Words	Epigenetic; DNA damage; DNA repair; DNA repair deficiency disorders; Epimutation; Genomic instability; Germ-line mutation; MicroRNAs; Precancerous conditions; Gastrointestinal cancer
Core Tip	The primary cause of cancer is DNA damage. DNA damage leads to replication errors and erroneous repair, and can result in driver mutations and epimu-tations. While germ-line mutations in DNA repair genes cause cancer-prone syndromes, mutations in DNA repair genes are infrequent in sporadic gastrointestinal cancers. However, reduction of DNA repair proteins due to epigenetic repression of DNA repair genes is very frequent and can cause early steps in sporadic cancers. Evaluation of which DNA repair pathway(s) are deficient in particular types of GI cancer and/or particular patients may prove useful in guiding choice of therapeutic agents.
Publish Date	2015-05-18 09:19
Citation	Bernstein C, Bernstein H. Epigenetic reduction of DNA repair in progression to gastrointestinal cancer. World J Gastrointest Oncol 2015; 7(5): 30-46
URL	http://www.wjgnet.com/1948-5204/full/v7/i5/30.htm
DOI	http://dx.doi.org/10.4251/wjgo.v7.i5.30

Full Article (PDF)	WJGO-7-30.pdf
Full Article (Word)	WJGO-7-30.doc
Manuscript File	15877-Review.doc
Answering Reviewers	15877-Answering reviewers.pdf
Audio Core Tip	15877-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	15877-Conflict-of-interest statement.pdf
Copyright License Agreement	15877-Copyright assignment.pdf
Peer-review Report	15877-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	15877-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	15877-Scientific misconduct check.pdf
Scientific Editor Work List	15877-Scientific editor work list.pdf