Publication Name	World Journal of Gastroenterology
Manuscript ID	15885
Country	Italy

Received	2014-12-16 09:40
Peer-Review Started	2014-12-16 11:42
To Make the First Decision	2015-01-22 16:44
Return for Revision	2015-01-30 16:49
Revised	2015-02-28 00:00
Second Decision	2015-03-25 16:47
Accepted by Journal Editor-in-Chief	2015-03-26 13:27
Accepted by Executive Editor-in-Chief	2015-03-31 09:47
Articles in Press	2015-03-31 11:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-05-19 15:56
Publish the Manuscript Online	2015-06-11 10:11

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Statistics & Probability
Manuscript Type	Editorial
Article Title	Short-term and long-term risk factors in gastric cancer
Manuscript Source	Invited Manuscript
All Author List	Giuseppe Verlato, Daniele Marrelli, Simone Accordini, Maria Bencivenga, Alberto Di Leo, Alberto Marchet, Roberto Petrioli, Giacomo Zoppini, Michele Muggeo, Franco Roviello and Giovanni de Manzoni
Funding Agency and Grant Number
Corresponding Author	Giuseppe Verlato, MD, PhD, Unit of Epidemiology and Medical Statistics, Department of Public Health and Community Medicine, University of Verona, Sezione di Epidemiologia e Statistica Medica, Istituti Biologici 2 B, Strada Le Grazie 8, 37134 Verona, Italy. giuseppe.verlato@univr.it
Key Words	Gastric cancer; Type 2 diabetes; Mortality; Short-term risk factors; Long-term risk factors; Survival analysis; Cox model; Proportional hazards assumption
Core Tip	In gastric cancer patients mortality from recurrence peaked in the first two years after curative gastrectomy and then declined. The prognostic significance of risk factors was not stable, as the effect of T and N decreased with time, while the effect of histology became apparent after two years. Advancing age was associated with increased post-operative mortality. Hence, the proportional hazards assumption of the Cox model was violated. A possible solution was to split survival analysis in the first two years of follow-up and subsequent years. By comparison, overall mortality and prognostic significance of risk factors was rather stable in a cohort of type 2 diabetic patients.
Publish Date	2015-06-11 10:11
Citation	Verlato G, Marrelli D, Accordini S, Bencivenga M, Di Leo A, Marchet A, Petrioli R, Zoppini G, Muggeo M, Roviello F, de Manzoni G. Short-term and long-term risk factors in gastric cancer. World J Gastroenterol 2015; 21(21): 6434-6443
URL	http://www.wjgnet.com/1007-9327/full/v21/i21/6434.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i21.6434

Full Article (PDF)	WJG-21-6434.pdf
Full Article (Word)	WJG-21-6434.doc
Manuscript File	15885-Review.doc
Answering Reviewers	15885-Answering reviewers.pdf
Audio Core Tip	15885-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	15885-Conflict-of-interest statement.pdf
Copyright License Agreement	15885-Copyright assignment.pdf
Peer-review Report	15885-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	15885-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	15885-Scientific misconduct check.pdf
Scientific Editor Work List	15885-Scientific editor work list.pdf