Publication Name	World Journal of Gastroenterology
Manuscript ID	1597
Country	China

Received	2012-12-21 23:13
Peer-Review Started	2012-12-22 16:02
To Make the First Decision	2013-03-18 15:22
Return for Revision	2013-03-19 20:55
Revised	2013-03-22 22:20
Second Decision	2013-05-09 14:02
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-05-10 06:44
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-06-07 09:26
Publish the Manuscript Online	2013-06-14 23:10

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Autobiography
Article Title	Combination treatment with comprehensive cryoablation and immunotherapy in metastatic hepatocellular cancer
Manuscript Source	Invited Manuscript
All Author List	Li-Zhi Niu, Jia-Liang Li, Jian-Ying Zeng, Feng Mu, Meng-Tian Liao, Fei Yao, Li Li, Chun-Yan Liu, Ji-Bing Chen, Jian-Sheng Zuo and Ke-Cheng Xu
Funding Agency and Grant Number
Corresponding Author	Ji-Bing Chen, MD, PhD, Surgical Department, Fuda Cancer Hospital, Jinan University School of Medicine, No. 2 Tangdexi Road, Tianhe District, Guangzhou 510665, Guangdong Province, China. fudaclab@gmail.com
Key Words	Cryoablation; Dendritic cell-cytokine-induced killer cell; Immunotherapy; Metastatic hepatocellular cancer; Survival time
Core Tip	Fourty-five patients of metastatic hepatocellular cancer were divided into cryo-immunotherapy, cryotherapy, immunotherapy and untreated groups. Median overall survival (OS) was higher following cryo-immunotherapy (32 mo) or cryotherapy (17.5 mo) than in the untreated group (3 mo); In the cryo-immunotherapy group, median OS was higher after multiple treatments (36.5 mo) than after a single treatment (21 mo). In a word, cryotherapy and, especially, cryo-immunotherapy significantly increased OS in metastatic hepatocellular cancer patients. Multiple cryo-immunotherapy was associated with a better prognosis than single cryo-immunotherapy.
Publish Date	2013-06-14 23:10
Citation	Niu LZ, Li JL, Zeng JY, Mu F, Liao MT, Yao F, Li L, Liu CY, Chen JB, Zuo JS, Xu KC. Combination treatment with comprehensive cryoablation and immunotherapy in metastatic hepatocellular cancer. World J Gastroenterol 2013; 19(22): 3473-3480
URL	http://www.wjgnet.com/1007-9327/full/v19/i22/3473.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i22.3473

Full Article (PDF)	WJG-19-3473.pdf
Manuscript File	1597-Review.doc
Answering Reviewers	1597-Answering reviewers.doc
Copyright License Agreement	1597-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	1597-Language certificate.pdf
Peer-review Report	1597-Peer review(s).pdf
Scientific Editor Work List	1597-Scientific editor work list.doc