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Articles Published Processes
6/18/2015 5:31:00 PM | Browse: 911 | Download: 1031
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Received |
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2014-12-21 11:47 |
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Peer-Review Started |
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2014-12-21 18:12 |
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To Make the First Decision |
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2015-01-08 16:54 |
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Return for Revision |
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2015-01-13 08:53 |
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Revised |
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2015-01-28 13:03 |
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Second Decision |
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2015-02-11 23:02 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2015-02-13 11:10 |
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Articles in Press |
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2015-02-13 11:32 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2015-03-31 09:48 |
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Typeset the Manuscript |
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2015-05-27 14:36 |
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Publish the Manuscript Online |
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2015-06-18 17:32 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Infectious Diseases |
| Manuscript Type |
Basic Study |
| Article Title |
Induction of endoplasmic reticulum-derived oxidative stress by an occult infection related S surface antigen variant
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
In-Kyung Lee, Seoung-Ae Lee, Hong Kim, You-Sub Won and Bum-Joon Kim |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Research Foundation of Korea grant funded by the Korea government |
2013-005810 |
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| Corresponding Author |
Bum-Joon Kim, Professor, Department of Microbiology and Immunology, Liver Research Institute, Cancer Research Institute and SNUMRC, College of Medicine, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 110-799, South Korea. kbumjoon@snu.ac.kr |
| Key Words |
Endoplasmic reticulum oxidative stress; Hepatitis B virus; KD variant; Colocalization; Reactive oxidative species; Apoptotic cell death |
| Core Tip |
The molecular mechanisms underlying the relationships between occult hepatitis B virus infection and liver disease progression remain a mystery. The present study demonstrated that the HBsAg variant KD, which exhibits a secretion defective phenotype, universally induced endoplasmic reticulum (ER) stress pathways in hepatocytes. This induction of ER stress may evoke ER stress-mediated biological actions that induce liver damaging processes, including ROS production, nitric oxide production, and apoptosis induction. In conclusion, occult infection related to hepatitis B virus S surface antigen variants may play a very pivotal role in the progression of liver diseases primarily via ER-derived oxidative stress and apoptosis in hepatocytes. |
| Publish Date |
2015-06-18 17:32 |
| Citation |
Lee IK, Lee SA, Kim H, Won YS, Kim BJ. Induction of endoplasmic reticulum-derived oxidative stress by an occult infection related S surface antigen variant. World J Gastroenterol 2015; 21(22): 6872-6883 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i22/6872.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i22.6872 |
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