Publication Name	World Journal of Gastroenterology
Manuscript ID	15977
Country	South Korea

Received	2014-12-21 11:47
Peer-Review Started	2014-12-21 18:12
First Decision by Editorial Office Director
Return for Revision	2015-01-13 08:53
Revised	2015-01-28 13:03
Publication Fee Transferred
Second Decision by Editor	2015-02-11 23:02
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2015-02-13 11:10
Articles in Press	2015-02-13 11:32
Edit the Manuscript by Language Editor	2015-03-31 09:48
Typeset the Manuscript	2015-05-27 14:36
Publish the Manuscript Online	2015-06-18 17:32

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Infectious Diseases
Manuscript Type	Basic Study
Article Title	Induction of endoplasmic reticulum-derived oxidative stress by an occult infection related S surface antigen variant
Manuscript Source	Unsolicited Manuscript
All Author List	In-Kyung Lee, Seoung-Ae Lee, Hong Kim, You-Sub Won and Bum-Joon Kim
Funding Agency and Grant Number	Funding Agency Grant Number National Research Foundation of Korea grant funded by the Korea government 2013-005810
Corresponding Author	Bum-Joon Kim, Professor, Department of Microbiology and Immunology, Liver Research Institute, Cancer Research Institute and SNUMRC, College of Medicine, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 110-799, South Korea. kbumjoon@snu.ac.kr
Key Words	Endoplasmic reticulum oxidative stress; Hepatitis B virus; KD variant; Colocalization; Reactive oxidative species; Apoptotic cell death
Core Tip	The molecular mechanisms underlying the relationships between occult hepatitis B virus infection and liver disease progression remain a mystery. The present study demonstrated that the HBsAg variant KD, which exhibits a secretion defective phenotype, universally induced endoplasmic reticulum (ER) stress pathways in hepatocytes. This induction of ER stress may evoke ER stress-mediated biological actions that induce liver damaging processes, including ROS production, nitric oxide production, and apoptosis induction. In conclusion, occult infection related to hepatitis B virus S surface antigen variants may play a very pivotal role in the progression of liver diseases primarily via ER-derived oxidative stress and apoptosis in hepatocytes.
Publish Date	2015-06-18 17:32
Citation	Lee IK, Lee SA, Kim H, Won YS, Kim BJ. Induction of endoplasmic reticulum-derived oxidative stress by an occult infection related S surface antigen variant. World J Gastroenterol 2015; 21(22): 6872-6883
URL	http://www.wjgnet.com/1007-9327/full/v21/i22/6872.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i22.6872

Full Article (PDF)	WJG-21-6872.pdf
Full Article (Word)	WJG-21-6872.doc
Manuscript File	15977-Review.doc
Answering Reviewers	15977-Answering reviewers.pdf
Audio Core Tip	15977-Audio core tip.m4a
Copyright License Agreement	15977-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	15977-Language certificate.pdf
Peer-review Report	15977-Peer-review(s).pdf
Scientific Misconduct Check	15977-Scientific misconduct check.pdf
Scientific Editor Work List	15977-Scientific editor work list.pdf