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5/30/2015 1:35:00 PM | Browse: 528 | Download: 840
Publication Name World Journal of Gastroenterology
Manuscript ID 16018
Country/Territory China
Received
2014-12-22 08:53
Peer-Review Started
2014-12-22 21:22
To Make the First Decision
2015-01-08 16:54
Return for Revision
2015-01-13 08:55
Revised
2015-01-22 17:39
Second Decision
2015-03-04 18:46
Accepted by Journal Editor-in-Chief
2015-03-05 21:44
Accepted by Company Editor-in-Chief
2015-03-12 16:37
Articles in Press
2015-03-12 16:46
Publication Fee Transferred
Edit the Manuscript by Language Editor
2015-04-02 20:47
Typeset the Manuscript
2015-05-17 17:24
Publish the Manuscript Online
2015-05-30 13:32
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Systematic Reviews
Article Title Integrative analysis of aberrant Wnt signaling in hepatitis B virus-related hepatocellular carcinoma
Manuscript Source Invited Manuscript
All Author List Shan-Long Ding, Zi-Wei Yang, Jie Wang, Xiao-Lei Zhang, Xiang-Mei Chen and Feng-Min Lu
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81372603
National Basic Research Program of China(973 Program) 2015CB554000
National S T Major Project for Infectious Diseases 2012ZX10004-904
111 Project B07001
Corresponding author Feng-Min Lu, PhD, Department of Microbiology and Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, 38 Xueyuan Road, Beijing 100191, China. lu.fengmin@bjmu.edu.cn
Key Words β-catenin; CTNNB1; Hepatitis B virus; Hepatocellular carcinoma; TP53; Wnt signaling
Core Tip Abnormal activation of Wnt/β-catenin signaling can be detected in approximately 50%-70% of hepatocellular carcinoma (HCC). It is necessary to take the analysis about the cause of Wnt/β-catenin signaling pathway aberration with the etiologic differences into consideration. In this review, the suggested genetic/epigenetic aberrations and their involvement in the abnormal Wnt/β-catenin overactivation in HCC were comprehensively analyzed, with focus on the cause of hepatitis B virus-related HCC. We suggest that genetic/epigenetic aberration of CTNNB1 and its protein degradation regulators are the major cause of Wnt signaling overactivation. TP53 gain-of-function mutation is seldom involved, and HBx-LINE1 chimeric transcripts created by viral integration may not be present.
Publish Date 2015-05-30 13:32
Citation Ding SL, Yang ZW, Wang J, Zhang XL, Chen XM, Lu FM. Integrative analysis of aberrant Wnt signaling in hepatitis B virus-related hepatocellular carcinoma. World J Gastroenterol 2015; 21(20): 6317-6328
Url http://www.wjgnet.com/1007-9327/full/v21/i20/6317.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i20.6317
Full Article (PDF) WJG-21-6317.pdf
Full Article (Word) WJG-21-6317.doc
Manuscript File 16018-Review.doc
Answering Reviewers 16018-Answering reviewers.pdf
Audio Core Tip 16018-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 16018-Conflict-of-interest statement.pdf
Copyright License Agreement 16018-Copyright assignment.pdf
Data Sharing Statement 16018-Data sharing statement.pdf
Peer-review Report 16018-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 16018-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 16018-Scientific misconduct check.pdf
Scientific Editor Work List 16018-Scientific editor work list.pdf