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Articles Published Processes
5/30/2015 1:35:00 PM | Browse: 1114 | Download: 1920
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Received |
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2014-12-22 08:53 |
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Peer-Review Started |
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2014-12-22 21:22 |
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To Make the First Decision |
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2015-01-08 16:54 |
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Return for Revision |
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2015-01-13 08:55 |
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Revised |
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2015-01-22 17:39 |
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Second Decision |
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2015-03-04 18:46 |
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Accepted by Journal Editor-in-Chief |
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2015-03-05 21:44 |
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Accepted by Executive Editor-in-Chief |
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2015-03-12 16:37 |
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Articles in Press |
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2015-03-12 16:46 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2015-04-02 20:47 |
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Typeset the Manuscript |
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2015-05-17 17:24 |
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Publish the Manuscript Online |
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2015-05-30 13:32 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Systematic Reviews |
| Article Title |
Integrative analysis of aberrant Wnt signaling in hepatitis B virus-related hepatocellular carcinoma
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Shan-Long Ding, Zi-Wei Yang, Jie Wang, Xiao-Lei Zhang, Xiang-Mei Chen and Feng-Min Lu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81372603 |
| National Basic Research Program of China（973 Program） |
2015CB554000 |
| National S T Major Project for Infectious Diseases |
2012ZX10004-904 |
| 111 Project |
B07001 |
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| Corresponding Author |
Feng-Min Lu, PhD, Department of Microbiology and Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, 38 Xueyuan Road, Beijing 100191, China. lu.fengmin@bjmu.edu.cn |
| Key Words |
β-catenin; CTNNB1; Hepatitis B virus; Hepatocellular carcinoma; TP53; Wnt signaling |
| Core Tip |
Abnormal activation of Wnt/β-catenin signaling can be detected in approximately 50%-70% of hepatocellular carcinoma (HCC). It is necessary to take the analysis about the cause of Wnt/β-catenin signaling pathway aberration with the etiologic differences into consideration. In this review, the suggested genetic/epigenetic aberrations and their involvement in the abnormal Wnt/β-catenin overactivation in HCC were comprehensively analyzed, with focus on the cause of hepatitis B virus-related HCC. We suggest that genetic/epigenetic aberration of CTNNB1 and its protein degradation regulators are the major cause of Wnt signaling overactivation. TP53 gain-of-function mutation is seldom involved, and HBx-LINE1 chimeric transcripts created by viral integration may not be present. |
| Publish Date |
2015-05-30 13:32 |
| Citation |
Ding SL, Yang ZW, Wang J, Zhang XL, Chen XM, Lu FM. Integrative analysis of aberrant Wnt signaling in hepatitis B virus-related hepatocellular carcinoma. World J Gastroenterol 2015; 21(20): 6317-6328 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i20/6317.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i20.6317 |
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