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7/6/2015 6:45:00 PM | Browse: 1158 | Download: 1918
Publication Name World Journal of Nephrology
Manuscript ID 16024
Country Greece
Received
2014-12-22 08:34
Peer-Review Started
2014-12-23 22:56
To Make the First Decision
2015-01-08 14:04
Return for Revision
2015-01-13 09:14
Revised
2015-02-03 06:31
Second Decision
2015-04-01 15:25
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2015-04-14 16:08
Articles in Press
2015-04-14 16:08
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-07-03 13:50
Publish the Manuscript Online
2015-07-06 18:45
ISSN 2220-6124 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Urology & Nephrology
Manuscript Type Prospective Study
Article Title Low T3 syndrome and long-term mortality in chronic hemodialysis patients
Manuscript Source Invited Manuscript
All Author List Stylianos Fragidis, Konstantinos Sombolos, Elias Thodis, Stylianos Panagoutsos, Euthymia Mourvati, Maria Pikilidou, Aikaterini Papagianni, Ploumis Pasadakis and Vasilios Vargemezis
Funding Agency and Grant Number
Corresponding Author Stylianos Fragidis, MD, Department of Nephrology, Medical School, Democritus University of Thrace, University Campus, 68100 Alexadroupolis, Greece. sfragidis@yahoo.com
Key Words C-reactive protein; Hemodialysis; Inflammation; Interleukin-6; Low T3 syndrome; Mortality
Core Tip Monthly blood samples were obtained from 114 patients for three consecutive months during the observation period for evaluation of thyroid function and measurement of inflammatory markers high sensitivity C-reactive protein (hsCRP) and interleukin-6 (IL-6). Patients were then followed-up for 7-years. Low mean freeT3 (< 1.8 pg/mL) emerged as a significant predictor of all-cause mortality after adjustment for age, diabetes mellitus, hypertension, hsCRP, serum creatinine and albumin. However, freeT3 was correlated with hsCRP, but not IL-6, and only at the first month suggesting that further studies are required to identify the underlying pathogenetic mechanisms of the association between thyroid function and survival.
Publish Date 2015-07-06 18:45
Citation Fragidis S, Sombolos K, Thodis E, Panagoutsos S, Mourvati E, Pikilidou M, Papagianni A, Pasadakis P, Vargemezis V. Low T3 syndrome and long-term mortality in chronic hemodialysis patients. World J Nephrol 2015; 4(3): 415-422
URL http://www.wjgnet.com/2220-6124/full/v4/i3/415.htm
DOI http://dx.doi.org/10.5527/wjn.v4.i3.415
Full Article (PDF) WJN-4-415.pdf
Full Article (Word) WJN-4-415.doc
Manuscript File 16024-Review.doc
Answering Reviewers 16024-Answering reviewers.pdf
Biostatistics Review Certificate 16024-Biostatistics statement.pdf
Clinical Trial Registration Statement 16024-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form 16024-Conflict-of-interest statement.pdf
Copyright License Agreement 16024-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s) 16024-Clinical trial registration statement.pdf
Institutional Review Board Approval Form or Document 16024-Institutional review board statement.pdf
Peer-review Report 16024-Peer-review(s).pdf
Scientific Misconduct Check 16024-Scientific misconduct check.pdf
Scientific Editor Work List 16024-Scientific editor work list.pdf