Publication Name	World Journal of Gastroenterology
Manuscript ID	16027
Country	China

Received	2014-12-23 09:49
Peer-Review Started	2014-12-23 12:15
To Make the First Decision	2015-03-10 20:14
Return for Revision	2015-03-12 14:23
Revised	2015-04-01 16:50
Second Decision	2015-05-04 08:15
Accepted by Journal Editor-in-Chief	2015-05-04 10:47
Accepted by Executive Editor-in-Chief	2015-05-21 17:16
Articles in Press	2015-05-21 17:17
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-06-08 06:29
Typeset the Manuscript	2015-06-26 14:06
Publish the Manuscript Online	2015-07-22 13:58

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Topic Highlights
Article Title	Clusterin: Review research progress and look ahead to direction in hepatocellular carcinoma
Manuscript Source	Invited Manuscript
All Author List	Peng Xiu, Xiao-Feng Dong, Xin-Ping Li and Jie Li
Funding Agency and Grant Number	Funding Agency Grant Number National Nature Science Foundation of China 81172331 National Nature Science Foundation of China 30972890 Shandong Provincial Medicine and Health Science Technology Development Planning, China 2013WS0145
Corresponding Author	Jie Li, MD, PhD, Department of General Surgery, Shandong Provincial Qianfoshan Hospital, Shandong University, No. 16766 Jingshi Road, Jinan 250014, Shandong Province, China. lijie0503@126.com
Key Words	Hepatocellular carcinoma; Clusterin; Custirsen; Chemotherapy; Antisense oligonucleotides
Core Tip	Resistance of liver cancer cells to chemotherapy continues to be a major clinical obstacle to extend the survival rate of patients with hepatocellular carcinoma (HCC). Custirsen, targeting secretory clusterin protein expression, is currently in clinical trials for patients with different cancers and considered to play a role in chemosensitization. This review is to summarize the current state of research on clusterin, to predict future research directions and to analyze the potential of the clinical application of custirsen in HCC.
Publish Date	2015-07-22 13:58
Citation	Xiu P, Dong XF, Li XP, Li J. Clusterin: Review of research progress and looking ahead to direction in hepatocellular carcinoma. World J Gastroenterol 2015; 21(27): 8262-8270
URL	http://www.wjgnet.com/1007-9327/full/v21/i27/8262.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i27.8262

Full Article (PDF)	WJG-21-8262.pdf
Full Article (Word)	WJG-21-8262.doc
Manuscript File	16027-Review.docx
Answering Reviewers	16027-Answering reviewers.pdf
Audio Core Tip	16027-Audio core tip.wma
Conflict-of-Interest Disclosure Form	16027-Conflict-of-interest statement.pdf
Copyright License Agreement	16027-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	16027-Language certificate.pdf
Peer-review Report	16027-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	16027-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	16027-Scientific misconduct check.pdf
Scientific Editor Work List	16027-Scientific editor work list.pdf