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Articles Published Processes
7/22/2015 2:02:00 PM | Browse: 991 | Download: 1983
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Received |
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2014-12-23 09:44 |
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Peer-Review Started |
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2014-12-23 12:34 |
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To Make the First Decision |
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2015-02-10 15:56 |
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Return for Revision |
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2015-02-13 10:55 |
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Revised |
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Second Decision |
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2015-05-16 15:02 |
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Accepted by Journal Editor-in-Chief |
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2015-05-19 02:37 |
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Accepted by Executive Editor-in-Chief |
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2015-05-21 17:17 |
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Articles in Press |
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2015-05-21 17:17 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2015-06-02 09:04 |
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Typeset the Manuscript |
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2015-06-30 14:20 |
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Publish the Manuscript Online |
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2015-07-22 13:58 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
TLR4–HMGB1-, MyD88- and TRIF-dependent signaling in mouse intestinal ischemia/reperfusion injury
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jie Wang, Gui-Zhen He, Yu-Kang Wang, Qian-Kun Zhu, Wei Chen and Tai Guo |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
30940069 |
| Natural Sciences Foundation of Beijing |
7102127 |
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| Corresponding Author |
Gui-Zhen He, Professor, Department of Parenteral and Enteral Nutrition, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No.1 Shuaifuyuan Wangfujing, Dongcheng District, Beijing 100730, China. hgzpumc@163.com |
| Key Words |
C57BL/6 mouse; Intestinal ischemia-reperfusion injury; High mobility group protein 1; Myeloid differentiation gene 88; Translocating-chain-associating membrane protein; Nuclear factor-κB |
| Core Tip |
Intestinal mucosal barrier injury induced by intestinal Ischemia/reperfusion (I/R) can often be the basis for a bad prognosis in many diseases. Although extensive investigative efforts have focused on it, the underlying mechanism remains the subject of debate and there are no effective methods for its prevention and control yet available. Our findings suggest that the high mobility group protein 1–toll-like receptor 4 axis and the two downstream signalling pathways all play important roles in I/R injury and show the potential therapeutic value of blocking these pathways. This study has an important clinical significance which could improve the survival rate and reduce complications in critically ill patients. |
| Publish Date |
2015-07-22 13:58 |
| Citation |
Wang J, He GZ,Wang YK, Zhu QK, Chen W, Guo T. TLR4-HMGB1-, MyD88- and TRIF-dependent signaling in mouse intestinal ischemia/reperfusion injury. World J Gastroenterol 2015; 21(27): 8314-8325 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i27/8314.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i27.8314 |
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