Publication Name	World Journal of Hepatology
Manuscript ID	16034
Country	Italy

Received	2014-12-23 09:30
Peer-Review Started	2014-12-24 11:38
To Make the First Decision	2015-02-07 14:51
Return for Revision	2015-02-10 11:31
Revised	2015-03-09 15:54
Second Decision	2015-03-16 18:06
Accepted by Journal Editor-in-Chief	2015-03-16 22:40
Accepted by Executive Editor-in-Chief	2015-04-14 16:09
Articles in Press	2015-04-14 16:09
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-05-27 17:33
Publish the Manuscript Online	2015-06-16 14:22

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Management of hepatocellular carcinoma in the elderly
Manuscript Source	Invited Manuscript
All Author List	Mauro Borzio, Elena Dionigi, Giancarlo Parisi, Ivana Raguzzi and Rodolfo Sacco
Funding Agency and Grant Number
Corresponding Author	Dr. Mauro Borzio, Unità di Gastroen­terologia, Azienda Ospedaliera di Melegnano, Via Pandina 1, 20070 Vizzolo Predabissi, Italy. mauro.borzio@gmail.com
Key Words	Hepatocarcinoma; Epidemiology; Cirrhosis; Elderly; Treatment
Core Tip	The number of elderly patients with cancer is expected to rise in the next future, and facing with elderly cirrhotic patients with hepatocellular carcinoma (HCC) will characterize liver oncology scenario in the near future. International guidelines do not specifically address how to approach HCC in aged patients and no recommendations are available on age threshold to which clinical decisions should refer. Available data seem to rule out an intrinsic negative impact of age itself on HCC prognosis, and treatment allocation should be decided mainly according to HCC stage, liver residual function and general conditions. Indeed, a nihilistic attitude to restrict treatment in this population is not longer justified.
Publish Date	2015-06-16 14:22
Citation	Borzio M, Dionigi E, Parisi G, Raguzzi I, Sacco R. Management of hepatocellular carcinoma in the elderly. World J Hepatol 2015; 7(11): 1521-1529
URL	http://www.wjgnet.com/1948-5182/full/v7/i11/1521.htm
DOI	http://dx.doi.org/10.4254/wjh.v7.i11.1521

Full Article (PDF)	WJH-7-1521.pdf
Full Article (Word)	WJH-7-1521.doc
Manuscript File	16034-Review.doc
Answering Reviewers	16034-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	16034-Conflict-of-interest statement.pdf
Copyright License Agreement	16034-Copyright assignment.pdf
Peer-review Report	16034-Peer-review(s).pdf
Scientific Misconduct Check	16034-Scientific misconduct check.pdf
Scientific Editor Work List	16034-Scientific editor work list.pdf