Publication Name	World Journal of Diabetes
Manuscript ID	16063
Country	Türkiye

Received	2014-12-24 09:19
Peer-Review Started	2014-12-26 15:28
To Make the First Decision	2015-02-07 14:54
Return for Revision	2015-02-10 14:13
Revised	2015-03-12 05:35
Second Decision	2015-09-02 15:39
Accepted by Journal Editor-in-Chief	2015-09-04 22:48
Accepted by Executive Editor-in-Chief	2015-09-08 15:52
Articles in Press	2015-09-08 15:52
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-09-25 21:22
Publish the Manuscript Online	2015-10-13 15:31

ISSN	1948-9358 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Endocrinology & Metabolism
Manuscript Type	Review
Article Title	Treatment of prediabetes
Manuscript Source	Invited Manuscript
All Author List	Mustafa Kanat, Ralph A DeFronzo and Muhammad A Abdul-Ghani
Funding Agency and Grant Number
Corresponding Author	Dr. Mustafa Kanat, MD, Division of Diabetes, Department of Internal Medicine, Istanbul Medipol University, TEM Avrupa Otoyolu Göztepe Çıkışı No: 1, Bağcılar, 34214 Istanbul, Turkey. mustafa.kanat@gmail.com
Key Words	Prediabetes; Impaired fasting glucose; Impared glucose tolerance; Diabetes prevention; Type 2 diabetes mellitus
Core Tip	Behavioral changes (dieting plus exercising) are effective in preventing impaired glucose tolerance (GT)-type 2 diabetes mellitus (type 2 DM) conversion as well as impaired fasting glucose (FG) - type 2 DM conversion but loosing weight is hard and also difficult to maintain. Pharmacological interventions (plus dieting and exer-cising) improving and preserving beta-cell function and enhancing insulin sensitivity may be suitable choices for high-risk IGT patients. Troglitazone in Prevention of Diabetes Study, Pioglitazone in Prevention of Diabetes Study, Diabetes Reduction Assessment with ramipril and rosiglitazone Medication Trial, Actos Now for the prevention of diabetes study and Diabetes Prevention Program have proven that thiazolidinediones obviously prevent the development of type 2 DM in IGT subjects as well as IFG subjects. In Diabetes Prevention Program and Indian Diabetes Prevention Program, metformin slowed down the progression of IGT to type 2 DM, and eventually American Diabetes Association Consensus Conference Statement proposed metfor-min usage in high-risk IGT individuals. However, the efficacy of pioglitazone and rosiglitazone efficacy in preventing IGT progression to type 2 DM nearly doubles metformin’s efficacy (31% vs 72% and 62%, respectively). Rosiglitazone (low dose = 2 mg/d) together with metformin (850 mg/d) was proven to slow down IGT progression to type 2 DM as well as being more tolerable.
Publish Date	2015-10-13 15:31
Citation	Kanat M, DeFronzo RA, Abdul-Ghani MA. Treatment of prediabetes. World J Diabetes 2015; 6(12): 1207-1222
URL	http://www.wjgnet.com/1948-9358/full/v6/i12/1207.htm
DOI	http://dx.doi.org/10.4239/wjd.v6.i12.1207

Full Article (PDF)	WJD-6-1207.pdf
Full Article (Word)	WJD-6-1207.doc
Manuscript File	16063-Review.docx
Answering Reviewers	16063-Answering reviewers.pdf
Audio Core Tip	16063-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	16063-Conflict-of-interest statement.pdf
Copyright License Agreement	16063-Copyright assignment.pdf
Peer-review Report	16063-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	16063-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	16063-Scientific misconduct check.pdf
Scientific Editor Work List	16063-Scientific editor work list.pdf