Publication Name	World Journal of Virology
Manuscript ID	16067
Country	United Kingdom

Received	2014-12-24 09:13
Peer-Review Started	2014-12-26 13:59
To Make the First Decision	2015-02-07 14:51
Return for Revision	2015-02-10 10:51
Revised	2015-03-19 00:09
Second Decision	2015-04-20 11:39
Accepted by Journal Editor-in-Chief	2015-04-22 11:11
Accepted by Executive Editor-in-Chief	2015-04-30 11:28
Articles in Press	2015-04-30 11:28
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-08-09 14:15
Publish the Manuscript Online	2015-08-13 10:30

ISSN	2220-3249 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Neurosciences
Manuscript Type	Review
Article Title	Prion-induced neurotoxicity: Possible role for cell cycle activity and DNA damage response
Manuscript Source	Invited Manuscript
All Author List	Raymond Bujdoso, Matthias Landgraf, Walker S Jackson and Alana M Thackray
Funding Agency and Grant Number	Funding Agency Grant Number NC3Rs NC/K000462/1 (in part)
Corresponding Author	Dr. Raymond Bujdoso, Department of Veterinary Medicine, University of Cambridge, Madingley Road, CB3 0ES Cambridge, United Kingdom. rb202@cam.ac.uk
Key Words	Neurodegenerative disease; Protein misfolding; Prion; Transmissible; Cell cycle; DNA repair; Chromatin; PrP transgenic Drosophila
Core Tip	It is important to understand the cellular and molecular mechanisms of protein misfolding-induced neurotoxicity in order to combat conditions such as Alzheimer’s, Huntington’s, Parkinson’s, and motor neuron disease, tauopathies and prion diseases. Here, we review the role of cell cycle activity and the DNA damage response in neurodegeneration associated with protein misfolding diseases, including prion diseases. In doing so, we highlight PrP transgenic Drosophila as a tractable model of transmissible mammalian prion disease. Our review provides a new impetus to the study of prion diseases, which are increasingly seen as an important paradigm for neurodegenerative conditions in general.
Publish Date	2015-08-13 10:30
Citation	Bujdoso R, Landgraf M, Jackson WS, Thackray AM. Prion-induced neurotoxicity: Possible role for cell cycle activity and DNA damage response. World J Virol 2015; 4(3): 188-197
URL	http://www.wjgnet.com/2220-3249/full/v4/i3/188.htm
DOI	http://dx.doi.org/10.5501/wjv.v4.i3.188

Full Article (PDF)	WJV-4-188.pdf
Full Article (Word)	WJV-4-188.doc
Manuscript File	16067-Review.doc
Answering Reviewers	16067-Answering reviewers.pdf
Audio Core Tip	16067-Audio core tip.wav
Conflict-of-Interest Disclosure Form	16067-Conflict-of-interest statement.pdf
Copyright License Agreement	16067-Copyright assignment.pdf
Peer-review Report	16067-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	16067-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	16067-Scientific misconduct check.pdf
Scientific Editor Work List	16067-Scientific editor work list.pdf